Paula Lario
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Molecular features of the copper binding sites in the octarepeat domain of the prion protein
CS Burns, E Aronoff-Spencer, CM Dunham, P Lario, NI Avdievich, ...
Biochemistry 41 (12), 3991-4001, 2002
Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox …
PI Lario, N Sampson, A Vrielink
Journal of molecular biology 326 (5), 1635-1650, 2003
Stable heterodimeric antibody design with mutations in the Fc domain
TS Von Kreudenstein, EE Cabrera, SB Dixit, PI Lario, DKY Poon
US Patent 9,562,109, 2017
Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion
AM Lambeir, C Durinx, P Proost, J Van Damme, S Scharpé, I De Meester
FEBS letters 507 (3), 327-330, 2001
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function
J Kim, A Thanabalasuriar, T Chaworth-Musters, JC Fromme, EA Frey, ...
Cell host & microbe 2 (3), 160-171, 2007
Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design
TS Von Kreudenstein, E Escobar-Carbrera, PI Lario, I D’Angelo, K Brault, ...
MAbs 5 (5), 646-654, 2013
Conformational difference between PDE4 apoenzyme and holoenzyme
F Laliberté, Y Han, A Govindarajan, A Giroux, S Liu, B Bobechko, P Lario, ...
Biochemistry 39 (21), 6449-6458, 2000
Structure and biochemical analysis of a secretin pilot protein
PI Lario, RA Pfuetzner, EA Frey, L Creagh, C Haynes, AT Maurelli, ...
The EMBO journal 24 (6), 1111-1121, 2005
Structural characterization of the type-III pilot-secretin complex from Shigella flexneri
M Okon, TF Moraes, PI Lario, AL Creagh, CA Haynes, NCJ Strynadka, ...
Structure 16 (10), 1544-1554, 2008
Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces
M Schubert, RE Edge, P Lario, MA Cook, NCJ Strynadka, GA Mackie, ...
Journal of molecular biology 341 (1), 37-54, 2004
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors
S Liu, F Laliberté, B Bobechko, A Bartlett, P Lario, E Gorseth, ...
Biochemistry 40 (34), 10179-10186, 2001
Computer housing for a portable computer
JC DiFonzo, A Johnston, SH Kim, B Andre
US Patent 6,570,757, 2003
The presence of a hydrogen bond between asparagine 485 and the π system of FAD modulates the redox potential in the reaction catalyzed by cholesterol oxidase
Y Yin, NS Sampson, A Vrielink, PI Lario
Biochemistry 40 (46), 13779-13787, 2001
Atomic resolution density maps reveal secondary structure dependent differences in electronic distribution
PI Lario, A Vrielink
Journal of the American Chemical Society 125 (42), 12787-12794, 2003
Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment
AY Lyubimov, PI Lario, I Moustafa, A Vrielink
Nature chemical biology 2 (5), 259-264, 2006
In vitro PKA phosphorylation‐mediated human PDE4A4 activation
F Laliberté, S Liu, E Gorseth, B Bobechko, A Bartlett, P Lario, MJ Gresser, ...
FEBS letters 512 (1-3), 205-208, 2002
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
AL Corper, D Urosev, SAL Tom-Yew, DWB Bleile, TS Von Kreudenstein, ...
US Patent 9,914,785, 2018
A new synthesis of in situ cyclopropanones and the observation of a thermal cyclopropanone–dienol rearrangement
C Black, P Lario, AP Masters, TS Sorensen, F Sun
Canadian journal of chemistry 71 (11), 1910-1918, 1993
Protein engineering and the use of molecular modeling and simulation: the case of heterodimeric Fc engineering
TS Von Kreudenstein, PI Lario, SB Dixit
Methods 65 (1), 77-94, 2014
Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain
TS Von Kreudenstein, E Escobar-Cabrera, GYK Ng, SB Dixit, PI Lario, ...
US Patent App. 14/989,648, 2016
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