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Heidi Koldsø
Heidi Koldsø
Scorpion Therapeutics
Verifierad e-postadress på scorpiontx.com
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Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers
H Koldsø, D Shorthouse, J Hélie, MSP Sansom
PLoS computational biology 10 (10), e1003911, 2014
2242014
The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids
G Hedger, MSP Sansom, H Koldsø
Scientific reports 5 (1), 9198, 2015
1142015
Organization and dynamics of receptor proteins in a plasma membrane
H Koldsø, MSP Sansom
Journal of the American Chemical Society 137 (46), 14694-14704, 2015
1042015
Membrane stiffness is modified by integral membrane proteins
PW Fowler, J Hélie, A Duncan, M Chavent, H Koldsø, MSP Sansom
Soft matter 12 (37), 7792-7803, 2016
992016
Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter
S Sinning, M Musgaard, M Jensen, K Severinsen, L Celik, H Koldsø, ...
Journal of biological chemistry 285 (11), 8363-8374, 2010
952010
The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations
H Koldsø, K Severinsen, TT Tran, L Celik, HH Jensen, O Wiborg, ...
Biophysical Journal 98 (3), 428a, 2010
912010
Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes
AL Duncan, T Reddy, H Koldsø, J Hélie, PW Fowler, M Chavent, ...
Scientific Reports 7 (1), 16647, 2017
852017
Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class FG protein-coupled receptor smoothened
G Hedger, H Koldsø, M Chavent, C Siebold, R Rohatgi, MSP Sansom
Structure 27 (3), 549-559. e2, 2019
802019
Monoamine transporters: insights from molecular dynamics simulations
J Grouleff, LK Ladefoged, H Koldsø, B Schiøtt
Frontiers in pharmacology 6, 159328, 2015
782015
Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations
KB Abd Halim, H Koldsø, MSP Sansom
Biochimica et Biophysica Acta (BBA)-General Subjects 1850 (5), 1017-1025, 2015
752015
Lipid-loving ANTs: molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes
G Hedger, SL Rouse, J Domański, M Chavent, H Koldsø, MSP Sansom
Biochemistry 55 (45), 6238-6249, 2016
612016
Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac)
J Andersen, N Stuhr-Hansen, LG Zachariassen, H Koldsø, B Schiøtt, ...
Molecular pharmacology 85 (5), 703-714, 2014
602014
Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Ion Release
H Koldsø, P Noer, J Grouleff, HE Autzen, S Sinning, B Schiøtt
PLoS computational biology 7 (10), e1002246, 2011
602011
Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations
H Koldsø, HE Autzen, J Grouleff, B Schiøtt
PLoS One 8 (6), e63635, 2013
592013
Comparative modeling of the human monoamine transporters: similarities in substrate binding
H Koldsø, AB Christiansen, S Sinning, B Schiøtt
ACS chemical neuroscience 4 (2), 295-309, 2013
582013
Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor
G Hedger, D Shorthouse, H Koldsø, MSP Sansom
The Journal of Physical Chemistry B 120 (33), 8154-8163, 2016
562016
Thermodynamic and structural investigation of the specific SDS binding of humicola insolens cutinase
D Kold, Z Dauter, AK Laustsen, AM Brzozowski, JP Turkenburg, ...
Protein Science 23 (8), 1023-1035, 2014
472014
Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural …
J Underhaug, H Koldsø, K Runager, JT Nielsen, CS Sørensen, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (12), 2812-2822, 2013
462013
Multiscale molecular dynamics simulations of lipid interactions with P-glycoprotein in a complex membrane
L Domicevica, H Koldsø, PC Biggin
Journal of Molecular Graphics and Modelling 80, 147-156, 2018
452018
Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndrome
T Storm, C Zeitz, O Cases, S Amsellem, PJ Verroust, M Madsen, ...
BMC medical genetics 14, 1-11, 2013
442013
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