Brent D. G. Page
Brent D. G. Page
Assistant Professor, University of British Columbia, and Karolinska Institute
Verified email at - Homepage
Cited by
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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
AM Eiring, BDG Page, IL Kraft, CC Mason, NA Vellore, D Resetca, ...
Leukemia 29 (3), 586-597, 2015
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
Signal transducer and activator of transcription 3 inhibitors: a patent review
BDG Page, DP Ball, PT Gunning
Expert opinion on therapeutic patents 21 (1), 65-83, 2011
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma
S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ...
ACS medicinal chemistry letters 4 (11), 1102-1107, 2013
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
M Carter, AS Jemth, A Hagenkort, BDG Page, R Gustafsson, JJ Griese, ...
Nature communications 6 (1), 1-10, 2015
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ...
Nature medicine 23 (2), 256-263, 2017
N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1 H)-pyridinones as agents for Alzheimer's therapy
LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ...
Chemical Science 2 (4), 642-648, 2011
NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine
NCK Valerie, A Hagenkort, BDG Page, G Masuyer, D Rehling, M Carter, ...
Cancer research 76 (18), 5501-5511, 2016
An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery
RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ...
Biomaterials 33 (5), 1500-1508, 2012
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ...
Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011
Antagonism of the Stat3–Stat3 protein dimer with salicylic acid based small molecules
S Fletcher, BDG Page, X Zhang, P Yue, ZH Li, S Sharmeen, J Singh, ...
ChemMedChem 6 (8), 1459, 2011
STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation
M Singh, N Garg, C Venugopal, R Hallett, T Tokar, N McFarlane, ...
Oncotarget 6 (29), 27461, 2015
STAT3 activity is necessary and sufficient for the development of immune‐mediated myocarditis in mice and promotes progression to dilated cardiomyopathy
A Camporeale, F Marino, A Papageorgiou, P Carai, S Fornero, S Fletcher, ...
EMBO molecular medicine 5 (4), 572-590, 2013
Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer
AZ Lai, S Cory, H Zhao, M Gigoux, A Monast, MC Guiot, S Huang, ...
Science signaling 7 (322), ra38-ra38, 2014
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against …
BDG Page, DC Croucher, ZH Li, S Haftchenary, VH Jimenez-Zepeda, ...
Journal of medicinal chemistry 56 (18), 7190-7200, 2013
Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease
LE Scott, BDG Page, BO Patrick, C Orvig
Dalton Transactions, 6364-6367, 2008
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
BDG Page, NCK Valerie, RHG Wright, O Wallner, R Isaksson, M Carter, ...
Nature communications 9 (1), 1-14, 2018
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