|Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts|
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012
|Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia|
AM Eiring, BDG Page, IL Kraft, CC Mason, NA Vellore, D Resetca, ...
Leukemia 29 (3), 586-597, 2015
|Signal transducer and activator of transcription 3 inhibitors: a patent review|
BDG Page, DP Ball, PT Gunning
Expert opinion on therapeutic patents 21 (1), 65-83, 2011
|Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein|
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
|Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities|
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009
|Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity|
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
|Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma|
S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ...
ACS medicinal chemistry letters 4 (11), 1102-1107, 2013
|Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2|
M Carter, AS Jemth, A Hagenkort, BDG Page, R Gustafsson, JJ Griese, ...
Nature communications 6 (1), 1-10, 2015
|Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies|
N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ...
Nature medicine 23 (2), 256-263, 2017
|N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1 H)-pyridinones as agents for Alzheimer's therapy|
LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ...
Chemical Science 2 (4), 642-648, 2011
|NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine|
NCK Valerie, A Hagenkort, BDG Page, G Masuyer, D Rehling, M Carter, ...
Cancer research 76 (18), 5501-5511, 2016
|An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery|
RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ...
Biomaterials 33 (5), 1500-1508, 2012
|Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain|
BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ...
Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011
|Antagonism of the Stat3–Stat3 protein dimer with salicylic acid based small molecules|
S Fletcher, BDG Page, X Zhang, P Yue, ZH Li, S Sharmeen, J Singh, ...
ChemMedChem 6 (8), 1459, 2011
|STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation|
M Singh, N Garg, C Venugopal, R Hallett, T Tokar, N McFarlane, ...
Oncotarget 6 (29), 27461, 2015
|STAT3 activity is necessary and sufficient for the development of immune‐mediated myocarditis in mice and promotes progression to dilated cardiomyopathy|
A Camporeale, F Marino, A Papageorgiou, P Carai, S Fornero, S Fletcher, ...
EMBO molecular medicine 5 (4), 572-590, 2013
|Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer|
AZ Lai, S Cory, H Zhao, M Gigoux, A Monast, MC Guiot, S Huang, ...
Science signaling 7 (322), ra38-ra38, 2014
|Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against …|
BDG Page, DC Croucher, ZH Li, S Haftchenary, VH Jimenez-Zepeda, ...
Journal of medicinal chemistry 56 (18), 7190-7200, 2013
|Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease|
LE Scott, BDG Page, BO Patrick, C Orvig
Dalton Transactions, 6364-6367, 2008
|Applying small molecule signal transducer and activator of transcription-3 (STAT3) protein inhibitors as pancreatic cancer therapeutics|
CC Arpin, S Mac, Y Jiang, H Cheng, M Grimard, BDG Page, MM Kamocka, ...
Molecular cancer therapeutics 15 (5), 794-805, 2016