Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance M Le Naour, E Akgün, A Yekkirala, MM Lunzer, MD Powers, ... Journal of medicinal chemistry 56 (13), 5505-5513, 2013 | 94 | 2013 |
An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia M Pravetoni, M Le Naour, TM Harmon, AM Tucker, PS Portoghese, ... Journal of Pharmacology and Experimental Therapeutics 341 (1), 225-232, 2012 | 93 | 2012 |
Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats M Pravetoni, MD Raleigh, M Le Naour, AM Tucker, TM Harmon, JM Jones, ... Vaccine 30 (31), 4617-4624, 2012 | 86 | 2012 |
A fentanyl vaccine alters fentanyl distribution and protects against fentanyl-induced effects in mice and rats MD Raleigh, F Baruffaldi, SJ Peterson, M Le Naour, TM Harmon, ... Journal of Pharmacology and Experimental Therapeutics 368 (2), 282-291, 2019 | 75 | 2019 |
Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens M Pravetoni, M Le Naour, AM Tucker, TM Harmon, TM Hawley, ... Journal of medicinal chemistry 56 (3), 915-923, 2013 | 66 | 2013 |
Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects M Le Naour, MM Lunzer, MD Powers, AE Kalyuzhny, MA Benneyworth, ... Journal of medicinal chemistry 57 (15), 6383-6392, 2014 | 42 | 2014 |
Effect of oxime ether incorporation in acyl indole derivatives on PPAR subtype selectivity M Le Naour, V Leclerc, A Farce, DH Caignard, N Hennuyer, B Staels, ... ChemMedChem 7 (12), 2179-2193, 2012 | 15 | 2012 |
Compositions and methods related to tauopathy KH Ashe, X Zhao, MA Walters, DJ Hook, MCP Le Naour US Patent 9,200,068, 2015 | 13 | 2015 |
Opioid Activity of Spinally Selective Analogues of N-Naphthoyl-β-naltrexamine in HEK-293 Cells and Mice M Le Naour, MM Lunzer, MD Powers, PS Portoghese Journal of medicinal chemistry 55 (2), 670-677, 2012 | 13 | 2012 |
Compositions and methods of treating opioid addiction PR Pentel, PS Portoghese, M Pravetoni, MCP Le Naour US Patent App. 14/029,568, 2014 | 8 | 2014 |
Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists A Hurtevent, M Le Naour, V Leclerc, P Carato, P Melnyk, N Hennuyer, ... Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 524-538, 2020 | 3 | 2020 |
Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens M Pravetoni, M Le Naour, AM Tucker, T Harmon, PS Portoghese, ... Drug and Alcohol Dependence 140, e180, 2014 | | 2014 |
JPET Fast Forward. Published on January 18, 2012 as DOI: 10.1124/jpet. 111.189506 M Pravetoni, M Le Naour, TM Harmon, AM Tucker, PS Portoghese, ... | | 2012 |
Heterocyclic Cycloalkyl Compounds, a Process for their Preparation and Pharmaceutical Compositions Containing Them A Hurtevent, JM L'Helgoual'ch, P Carato, N Lebegue, V Leclerc, ... US Patent App. 12/224,861, 2009 | | 2009 |
New heterocyclic compounds are aldose reductase inhibitors useful to treat e.g. hyperglycemia, dyslipidemia, non-insulin-dependant type II diabetes, syndrome X, coronary artery … LEN MORGAN, P CELINE, L NICOLAS, L VERONIQUE, B PASCAL, ... FR Patent FR2921366 (A1), 2007 | | 2007 |
NOUVEAUX DERIVES TETRACYCLIQUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT LHCHJ MARTIAL, LEN MORGAN, B PASCAL, L NICOLAS, ... FR Patent FR2903404 (A1), 2006 | | 2006 |