Morgan DeSantis
Morgan DeSantis
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TitleCited byYear
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events
ME Jackrel, ME DeSantis, BA Martinez, LM Castellano, RM Stewart, ...
Cell 156 (1-2), 170-182, 2014
Mechanism and regulation of cytoplasmic dynein
MA Cianfrocco, ME DeSantis, AE Leschziner, SL Reck-Peterson
Annual review of cell and developmental biology 31, 83-108, 2015
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients
ME DeSantis, EH Leung, EA Sweeny, ME Jackrel, M Cushman-Nick, ...
Cell 151 (4), 778-793, 2012
Fission yeast does not age under favorable conditions, but does so after stress
M Coelho, A Dereli, A Haese, S Kühn, L Malinovska, ME DeSantis, ...
Current Biology 23 (19), 1844-1852, 2013
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
Cell 173 (3), 677-692. e20, 2018
The elusive middle domain of Hsp104 and ClpB: location and function
ME DeSantis, J Shorter
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (1), 29-39, 2012
The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation
EA Sweeny, ME Jackrel, MS Go, MA Sochor, BM Razzo, ME DeSantis, ...
Molecular cell 57 (5), 836-849, 2015
Hsp104 drives “protein-only” positive selection of Sup35 prion strains encoding strong [PSI+]
ME DeSantis, J Shorter
Chemistry & biology 19 (11), 1400-1410, 2012
The human cytoplasmic dynein interactome reveals novel activators of motility
WB Redwine, ME DeSantis, I Hollyer, ZM Htet, PT Tran, SK Swanson, ...
Elife 6, e28257, 2017
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation
ME DeSantis, EA Sweeny, D Snead, EH Leung, MS Go, K Gupta, ...
Journal of Biological Chemistry 289 (2), 848-867, 2014
Association energetics of cross-reactive and specific antibodies
S Mohan, K Kourentzi, KA Schick, C Uehara, CA Lipschultz, M Acchione, ...
Biochemistry 48 (6), 1390-1398, 2009
Lis1 has two opposing modes of regulating cytoplasmic dynein
ME DeSantis, MA Cianfrocco, ZM Htet, PT Tran, SL Reck-Peterson, ...
Cell 170 (6), 1197-1208. e12, 2017
Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies
M Acchione, CA Lipschultz, ME DeSantis, A Shanmuganathan, M Li, ...
Molecular immunology 47 (2-3), 457-464, 2009
Purification of hsp104, a protein disaggregase
EA Sweeny, ME DeSantis, J Shorter
JoVE (Journal of Visualized Experiments), e3190, 2011
Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics
M Acchione, YC Lee, ME DeSantis, CA Lipschultz, A Wlodawer, M Li, ...
Biochemistry 51 (30), 6017-6027, 2012
Preventing Parkinson’s pathology
ME DeSantis, D Dersh
Disease models & mechanisms 3 (7-8), 399-400, 2010
Lis1 promotes the formation of maximally activated cytoplasmic dynein-1 complexes
ZM Htet, JP Gillies, RW Baker, AE Leschziner, ME DeSantis, ...
bioRxiv, 683052, 2019
Two Opposing Modes of Cytoplasmic Dynein Regulation by Lis1
ZM Htet, ME DeSantis, MA Cianfrocco, PT Tran, AE Leschziner, ...
Biophysical Journal 114 (3), 512a, 2018
Mechanisms of Regulating Cytoplasmic Dynein
S Reck-Peterson, A Leschziner, M DeSantis, M Cianfrocco, ZM Htet, ...
Biophysical Journal 114 (3), 9a, 2018
Lis1 has Two Distinct Modes of Regulating Dynein's Mechanochemical Cycle
MA Cianfrocco, ME DeSantis, ZM Htet, PT Tran, AE Leschziner, ...
Biophysical Journal 112 (3), 43a, 2017
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Articles 1–20