Morgan DeSantis
Morgan DeSantis
Verified email at ucsd.edu
TitleCited byYear
Mechanism and regulation of cytoplasmic dynein
MA Cianfrocco, ME DeSantis, AE Leschziner, SL Reck-Peterson
Annual review of cell and developmental biology 31, 83-108, 2015
1342015
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events
ME Jackrel, ME DeSantis, BA Martinez, LM Castellano, RM Stewart, ...
Cell 156 (1-2), 170-182, 2014
1342014
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients
ME DeSantis, EH Leung, EA Sweeny, ME Jackrel, M Cushman-Nick, ...
Cell 151 (4), 778-793, 2012
1272012
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
Cell 173 (3), 677-692. e20, 2018
892018
Fission yeast does not age under favorable conditions, but does so after stress
M Coelho, A Dereli, A Haese, S Kühn, L Malinovska, ME DeSantis, ...
Current Biology 23 (19), 1844-1852, 2013
872013
The elusive middle domain of Hsp104 and ClpB: location and function
ME DeSantis, J Shorter
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (1), 29-39, 2012
652012
The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation
EA Sweeny, ME Jackrel, MS Go, MA Sochor, BM Razzo, ME DeSantis, ...
Molecular cell 57 (5), 836-849, 2015
632015
The human cytoplasmic dynein interactome reveals novel activators of motility
WB Redwine, ME DeSantis, I Hollyer, ZM Htet, PT Tran, SK Swanson, ...
Elife 6, e28257, 2017
392017
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation
ME DeSantis, EA Sweeny, D Snead, EH Leung, MS Go, K Gupta, ...
Journal of Biological Chemistry 289 (2), 848-867, 2014
362014
Hsp104 drives “protein-only” positive selection of Sup35 prion strains encoding strong [PSI+]
ME DeSantis, J Shorter
Chemistry & biology 19 (11), 1400-1410, 2012
362012
Lis1 has two opposing modes of regulating cytoplasmic dynein
ME DeSantis, MA Cianfrocco, ZM Htet, PT Tran, SL Reck-Peterson, ...
Cell 170 (6), 1197-1208. e12, 2017
332017
Association energetics of cross-reactive and specific antibodies
S Mohan, K Kourentzi, KA Schick, C Uehara, CA Lipschultz, M Acchione, ...
Biochemistry 48 (6), 1390-1398, 2009
302009
Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies
M Acchione, CA Lipschultz, ME DeSantis, A Shanmuganathan, M Li, ...
Molecular immunology 47 (2-3), 457-464, 2009
242009
Purification of hsp104, a protein disaggregase
EA Sweeny, ME DeSantis, J Shorter
JoVE (Journal of Visualized Experiments), e3190, 2011
162011
Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics
M Acchione, YC Lee, ME DeSantis, CA Lipschultz, A Wlodawer, M Li, ...
Biochemistry 51 (30), 6017-6027, 2012
92012
Preventing Parkinson’s pathology
ME DeSantis, D Dersh
Disease models & mechanisms 3 (7-8), 399-400, 2010
52010
Lis1 promotes the formation of maximally activated cytoplasmic dynein-1 complexes
ZM Htet, JP Gillies, RW Baker, AE Leschziner, ME DeSantis, ...
bioRxiv, 683052, 2019
22019
Lis1 Promotes the Formation of Activated Cytoplasmic Dynein-1 Complexes
JP Gillies, ZM Htet, RW Baker, A Leschziner, ME DeSantis, ...
Biophysical Journal 118 (3), 428a-429a, 2020
2020
Nuclear-import receptors reverse aberrant phase transitions of disease-linked RNA-binding proteins with prion-like domains.
L Guo, H Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018
2018
Lis1 promotes the formation of maximally activated dynein complexes.
JP Gillies, ZM Htet, ME DeSantis, SL Reck-Peterson
MOLECULAR BIOLOGY OF THE CELL 29 (26), 2018
2018
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Articles 1–20