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HE Bryant, N Schultz, HD Thomas, KM Parker, D Flower, E Lopez, S Kyle, ...
Nature 434 (7035), 913-917, 2005
|Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints|
J Bartkova, N Rezaei, M Liontos, P Karakaidos, D Kletsas, N Issaeva, ...
Nature 444 (7119), 633-637, 2006
|DNA repair pathways as targets for cancer therapy|
T Helleday, E Petermann, C Lundin, B Hodgson, RA Sharma
Nature Reviews Cancer 8 (3), 193-204, 2008
|DNA double-strand break repair: from mechanistic understanding to cancer treatment|
T Helleday, J Lo, DC van Gent, BP Engelward
DNA repair 6 (7), 923-935, 2007
|Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair|
E Petermann, ML Orta, N Issaeva, N Schultz, T Helleday
Molecular cell 37 (4), 492-502, 2010
|The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair|
CS Sørensen, LT Hansen, J Dziegielewski, RG Syljuåsen, C Lundin, ...
Nature cell biology 7 (2), 195-201, 2005
|Mechanisms underlying mutational signatures in human cancers|
T Helleday, S Eshtad, S Nik-Zainal
Nature Reviews Genetics 15 (9), 585-598, 2014
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RG Syljuåsen, CS Sørensen, LT Hansen, K Fugger, C Lundin, ...
Molecular and cellular biology 25 (9), 3553-3562, 2005
|Replication stress links structural and numerical cancer chromosomal instability|
RA Burrell, SE McClelland, D Endesfelder, P Groth, MC Weller, N Shaikh, ...
Nature 494 (7438), 492-496, 2013
|The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings|
Molecular oncology 5 (4), 387-393, 2011
|PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination|
HE Bryant, E Petermann, N Schultz, AS Jemth, O Loseva, N Issaeva, ...
The EMBO journal 28 (17), 2601-2615, 2009
|DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells|
C Arnaudeau, C Lundin, T Helleday
Journal of molecular biology 307 (5), 1235-1245, 2001
|miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors|
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Molecular cell 41 (2), 210-220, 2011
|Pathways for mitotic homologous recombination in mammalian cells|
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|Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1|
SF El-Khamisy, GM Saifi, M Weinfeld, F Johansson, T Helleday, JR Lupski, ...
Nature 434 (7029), 108-113, 2005
|Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks|
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Nucleic acids research 33 (12), 3799-3811, 2005
|Pathways of mammalian replication fork restart|
E Petermann, T Helleday
Nature reviews Molecular cell biology 11 (10), 683-687, 2010
|Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks|
N Saleh-Gohari, HE Bryant, N Schultz, KM Parker, TN Cassel, T Helleday
Molecular and cellular biology 25 (16), 7158-7169, 2005
|MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool|
H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ...
Nature 508 (7495), 215-221, 2014
|Poly (ADP‐ribose) polymerase (PARP‐1) has a controlling role in homologous recombination|
N Schultz, E Lopez, N Saleh‐Gohari, T Helleday
Nucleic acids research 31 (17), 4959-4964, 2003