Thomas Helleday
Thomas Helleday
Verified email at sheffield.ac.uk - Homepage
Title
Cited by
Cited by
Year
Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
HE Bryant, N Schultz, HD Thomas, KM Parker, D Flower, E Lopez, S Kyle, ...
Nature 434 (7035), 913-917, 2005
39812005
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
J Bartkova, N Rezaei, M Liontos, P Karakaidos, D Kletsas, N Issaeva, ...
Nature 444 (7119), 633-637, 2006
18422006
DNA repair pathways as targets for cancer therapy
T Helleday, E Petermann, C Lundin, B Hodgson, RA Sharma
Nature Reviews Cancer 8 (3), 193-204, 2008
15102008
DNA double-strand break repair: from mechanistic understanding to cancer treatment
T Helleday, J Lo, DC van Gent, BP Engelward
DNA repair 6 (7), 923-935, 2007
7302007
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
E Petermann, ML Orta, N Issaeva, N Schultz, T Helleday
Molecular cell 37 (4), 492-502, 2010
6452010
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
CS Sørensen, LT Hansen, J Dziegielewski, RG Syljuåsen, C Lundin, ...
Nature cell biology 7 (2), 195-201, 2005
6072005
Mechanisms underlying mutational signatures in human cancers
T Helleday, S Eshtad, S Nik-Zainal
Nature Reviews Genetics 15 (9), 585-598, 2014
5972014
Replication stress links structural and numerical cancer chromosomal instability
RA Burrell, SE McClelland, D Endesfelder, P Groth, MC Weller, N Shaikh, ...
Nature 494 (7438), 492-496, 2013
5792013
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
T Helleday
Molecular oncology 5 (4), 387-393, 2011
5622011
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
RG Syljuåsen, CS Sørensen, LT Hansen, K Fugger, C Lundin, ...
Molecular and cellular biology 25 (9), 3553-3562, 2005
5512005
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
HE Bryant, E Petermann, N Schultz, AS Jemth, O Loseva, N Issaeva, ...
The EMBO journal 28 (17), 2601-2615, 2009
5232009
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
C Arnaudeau, C Lundin, T Helleday
Journal of molecular biology 307 (5), 1235-1245, 2001
4472001
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors
P Moskwa, FM Buffa, Y Pan, R Panchakshari, P Gottipati, RJ Muschel, ...
Molecular cell 41 (2), 210-220, 2011
4222011
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
SF El-Khamisy, GM Saifi, M Weinfeld, F Johansson, T Helleday, JR Lupski, ...
Nature 434 (7029), 108-113, 2005
3902005
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
C Lundin, M North, K Erixon, K Walters, D Jenssen, ASH Goldman, ...
Nucleic acids research 33 (12), 3799-3811, 2005
3872005
Pathways for mitotic homologous recombination in mammalian cells
T Helleday
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 532 (1 …, 2003
3832003
Pathways of mammalian replication fork restart
E Petermann, T Helleday
Nature reviews Molecular cell biology 11 (10), 683-687, 2010
3712010
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ...
Nature 508 (7495), 215-221, 2014
3652014
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
N Saleh-Gohari, HE Bryant, N Schultz, KM Parker, TN Cassel, T Helleday
Molecular and cellular biology 25 (16), 7158-7169, 2005
3462005
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
N Saleh-Gohari, T Helleday
Nucleic acids research 32 (12), 3683-3688, 2004
3282004
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