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Dun-Sheng Yang, Ph.D.
Dun-Sheng Yang, Ph.D.
Senior Research Scientist (Tenured), Nathan Kline Institute
Verifierad e-postadress på nki.rfmh.org - Startsida
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th Edition)
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 17 (1), 1-382, 2021
13446*2021
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
G Yu, M Nishimura, S Arawaka, D Levitan, L Zhang, A Tandon, YQ Song, ...
Nature 407 (6800), 48-54, 2000
12872000
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
MA Chishti, DS Yang, C Janus, AL Phinney, P Horne, J Pearson, ...
Journal of Biological Chemistry 276 (24), 21562-21570, 2001
11912001
Autophagy failure in Alzheimer's disease—locating the primary defect
RA Nixon, DS Yang
Neurobiology of disease 43 (1), 38-45, 2011
6782011
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
DS Yang, P Stavrides, PS Mohan, S Kaushik, A Kumar, M Ohno, ...
Brain 134 (1), 258-277, 2011
4852011
Neurodegenerative lysosomal disorders: a continuum from development to late age
RA Nixon, DS Yang, JH Lee
Autophagy 4 (5), 590-599, 2008
4142008
Modulating factors in amyloid-β fibril formation
J McLaurin, DS Yang, CM Yip, PE Fraser
Journal of Structural Biology 130 (2-3), 259-270, 2000
3372000
Manipulating the amyloid-β aggregation pathway with chemical chaperones
DS Yang, CM Yip, THJ Huang, A Chakrabartty, PE Fraser
Journal of Biological Chemistry 274 (46), 32970-32974, 1999
3171999
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
JH Lee, DS Yang, CN Goulbourne, E Im, P Stavrides, A Pensalfini, ...
Nature neuroscience 25 (6), 688-701, 2022
2852022
Structural studies of soluble oligomers of the Alzheimer β-amyloid peptide
TH Huang, DS Yang, NP Plaskos, S Go, CM Yip, PE Fraser, ...
Journal of molecular biology 297 (1), 73-87, 2000
2562000
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
DS Yang, A Kumar, P Stavrides, J Peterson, CM Peterhoff, M Pawlik, ...
The American journal of pathology 173 (3), 665-681, 2008
2102008
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
DS Yang, A Tandon, F Chen, G Yu, H Yu, S Arawaka, H Hasegawa, ...
Journal of Biological Chemistry 277 (31), 28135-28142, 2002
2072002
Autophagy and neuronal cell death in neurological disorders
RA Nixon, DS Yang
Cold Spring Harbor Perspectives in Biology 4 (10), 2012
1982012
Copper (II)-induced conformational changes and protease resistance in recombinant and cellular PrP effect of protein age and deamidation
K Qin, DS Yang, Y Yang, MA Chishti, LJ Meng, HA Kretzschmar, CM Yip, ...
Journal of Biological Chemistry 275 (25), 19121-19131, 2000
1982000
Presenilin structure, function and role in Alzheimer disease
PE Fraser, DS Yang, G Yu, L Lévesque, M Nishimura, S Arawaka, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1502 (1), 1-15, 2000
1522000
Examining the zinc binding site of the amyloid‐β peptide
DS Yang, JA McLaurin, K Qin, D Westaway, PE Fraser
European Journal of Biochemistry 267 (22), 6692-6698, 2000
1482000
Characterization of the Binding of Amyloid‐β Peptide to Cell Culture‐Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma
DS Yang, JD Smith, Z Zhou, SE Gandy, RN Martins
Journal of neurochemistry 68 (2), 721-725, 1997
1431997
Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner
DS Yang, DH Small, U Seydel, JD Smith, J Hallmayer, SE Gandy, ...
Neuroscience 90 (4), 1217-1226, 1999
1411999
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
MV Rao, PS Mohan, CM Peterhoff, DS Yang, SD Schmidt, PH Stavrides, ...
Journal of Neuroscience 28 (47), 12241-12254, 2008
1382008
Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer’s disease
X Xue, LR Wang, Y Sato, Y Jiang, M Berg, DS Yang, RA Nixon, XJ Liang
Nano letters 14 (9), 5110-5117, 2014
1202014
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Artiklar 1–20