Follow
John F. Kellie
John F. Kellie
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Mapping intact protein isoforms in discovery mode using top-down proteomics
JC Tran, L Zamdborg, DR Ahlf, JE Lee, AD Catherman, KR Durbin, ...
Nature 480 (7376), 254-258, 2011
7462011
Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry
JF Kellie, RE Higgs, JW Ryder, A Major, TG Beach, CH Adler, K Merchant, ...
Scientific reports 4 (1), 5797, 2014
1592014
The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput
JF Kellie, JC Tran, JE Lee, DR Ahlf, HM Thomas, I Ntai, AD Catherman, ...
Molecular BioSystems 6 (9), 1532-1539, 2010
1312010
Size-sorting combined with improved nanocapillary liquid chromatography− mass spectrometry for identification of intact proteins up to 80 kDa
A Vellaichamy, JC Tran, AD Catherman, JE Lee, JF Kellie, SMM Sweet, ...
Analytical chemistry 82 (4), 1234-1244, 2010
1132010
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome
JE Lee, JF Kellie, JC Tran, JD Tipton, AD Catherman, HM Thomas, ...
Journal of the American Society for Mass Spectrometry 20, 2183-2191, 2009
1092009
Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry
JF Kellie, AD Catherman, KR Durbin, JC Tran, JD Tipton, JL Norris, ...
Analytical chemistry 84 (1), 209-215, 2012
672012
Intact mass detection, interpretation, and visualization to automate Top‐Down proteomics on a large scale
KR Durbin, JC Tran, L Zamdborg, SMM Sweet, AD Catherman, JE Lee, ...
Proteomics 10 (20), 3589-3597, 2010
582010
Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa
JD Tipton, JC Tran, AD Catherman, DR Ahlf, KR Durbin, JE Lee, JF Kellie, ...
Analytical chemistry 84 (5), 2111-2117, 2012
482012
A whole-molecule immunocapture LC–MS approach for the in vivo quantitation of biotherapeutics
JF Kellie, JR Kehler, TJ Mencken, RJ Snell, CS Hottenstein
Bioanalysis 8 (20), 2103-2114, 2016
412016
Intact protein mass spectrometry for therapeutic protein quantitation, pharmacokinetics, and biotransformation in preclinical and clinical studies: an industry perspective
JF Kellie, JC Tran, W Jian, B Jones, JT Mehl, Y Ge, J Henion, KP Bateman
Journal of the American Society for Mass Spectrometry 32 (8), 1886-1900, 2020
292020
IQ consortium perspective: complementary LBA and LC–MS in protein therapeutics bioanalysis and biotransformation assessment
S Kaur, KP Bateman, J Glick, M Jairaj, J F Kellie, J Sydor, J Zeng
Bioanalysis 12 (4), 257-270, 2020
272020
Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects
K Fang, CL Bowen, JF Kellie, MZ Karlinsey, CA Evans
Bioanalysis 10 (4), 241-255, 2018
272018
2019 White paper on recent issues in bioanalysis: chromatographic assays (part 1–innovation in small molecules and oligonucleotides & mass spectrometric method development …
C Fandozzi, C Evans, A Wilson, D Su, M Anderson, V Clausen, L Dillen, ...
Bioanalysis 11 (22), 2029-2048, 2019
252019
Application of high-resolution MS for development of peptide and large-molecule drug candidates
JF Kellie, JR Kehler, ME Szapacs
Bioanalysis 8 (3), 169-177, 2016
242016
Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis
JF Kellie, JR Kehler, MZ Karlinsey, SG Summerfield
Bioanalysis 9 (23), 1883-1893, 2017
222017
Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS
JF Kellie, MZ Karlinsey
Bioanalysis 10 (22), 1877-1890, 2018
202018
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1 …
S Kaur, SC Alley, M Szapacs, A Wilson, E Ciccimaro, D Su, N Henderson, ...
Bioanalysis 14 (9), 505-580, 2022
162022
Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid
H Lee, HV Le, R Wu, E Doud, R Sanishvili, JF Kellie, PD Compton, ...
ACS chemical biology 10 (9), 2087-2098, 2015
162015
Antibody subunit LC-MS analysis for pharmacokinetic and biotransformation determination from in-life studies for complex biotherapeutics
JF Kellie, KE Pannullo, Y Li, K Fraley, A Mayer, CJ Sychterz, ME Szapacs, ...
Analytical Chemistry 92 (12), 8268-8277, 2020
122020
Biotherapeutic antibody subunit LC-MS and peptide mapping LC-MS measurements to study possible biotransformation and critical quality attributes in vivo
JF Kellie, AS Thomson, S Chen, SL Childs, MZ Karlinsey, SH Mai, ...
Journal of Pharmaceutical Sciences 108 (4), 1415-1422, 2019
122019
The system can't perform the operation now. Try again later.
Articles 1–20