Mikael Widersten
Mikael Widersten
Professor of Biochemistry, Uppsala University
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Nomenclature for human glutathione transferases.
B Mannervik, YC Awasthi, PG Board, JD Hayes, C Di Ilio, B Ketterer, ...
Biochemical Journal 282 (Pt 1), 305, 1992
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases.
K Berhane, M Widersten, Å Engström, JW Kozarich, B Mannervik
Proceedings of the National Academy of Sciences 91 (4), 1480-1484, 1994
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative …
S Baez, J Segura-Aguilar, M Widersten, AS Johansson, B Mannervik
Biochemical Journal 324 (1), 25-28, 1997
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
K Sundberg, AS Johansson, G Stenberg, M Widersten, A Seidel, ...
Carcinogenesis 19 (3), 433-436, 1998
Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis
D Lindberg, M de la Fuente Revenga, M Widersten
Journal of biotechnology 147 (3-4), 169-171, 2010
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105
AS Johansson, G Stenberg, M Widersten, B Mannervik
Journal of molecular biology 278 (3), 687-698, 1998
Glutathione conjugation of bay-and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1
K Sundberg, M Widersten, A Seidel, B Mannervik, B Jernström
Chemical research in toxicology 10 (11), 1221-1227, 1997
Glutathione transferases with novel active sites isolated by phage display from a library of random mutants
M Widersten, B Mannervik
Journal of molecular biology 250 (2), 115-122, 1995
Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome
J Segura-Aguilar, S Baez, M Widersten, CJ Welch, B Mannervik
Journal of Biological Chemistry 272 (9), 5727-5731, 1997
Heterologous expression of the allelic variant mu-class glutathione transferases μ and ψ
M Widersten, WR Pearson, A Engström, B Mannervik
Biochemical Journal 276 (2), 519-524, 1991
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1
R Björnestedt, G Stenberg, M Widersten, PG Board, I Sinning, TA Jones, ...
Journal of molecular biology 247 (4), 765-773, 1995
Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance
S Mukanganyama, M Widersten, YS Naik, B Mannervik, JA Hasler
International journal of cancer 97 (5), 700-705, 2002
Structure–function relationships of epoxide hydrolases and their potential use in biocatalysis
M Widersten, A Gurell, D Lindberg
Biochimica et Biophysica Acta (BBA)-General Subjects 1800 (3), 316-326, 2010
Conjugation of highly reactive aflatoxin B1 exo-8, 9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters
WW Johnson, YF Ueng, M Widersten, B Mannervik, JD Hayes, PJ Sherratt, ...
Biochemistry 36 (11), 3056-3060, 1997
Human glutathione transferases: classification, tissue distribution, structure, and functional properties
B Mannervik, M Widersten
Advances in drug metabolism in man, 407-459, 1995
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes
VM Castro, M Söderström, I Carlberg, M Widersten, A Platz, B Mannervik
Carcinogenesis 11 (9), 1569-1576, 1990
X‐ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes
SL Mowbray, LT Elfström, KM Ahlgren, CE Andersson, M Widersten
Protein Science 15 (7), 1628-1637, 2006
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1
M Widersten, R Björnestedt, B Mannervik
Biochemistry 35 (24), 7731-7742, 1996
A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes
KE Comstock, M Widersten, XY Hao, WD Henner, B Mannervik
Archives of biochemistry and biophysics 311 (2), 487-495, 1994
Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1
M Widersten, RH Kolm, R Björnestedt, B Mannervik
Biochemical Journal 285 (2), 377-381, 1992
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