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John G. Cumming, PhD
John G. Cumming, PhD
Experienced medicinal chemist, AstraZeneca Pharmaceuticals
Verifierad e-postadress på astrazeneca.com
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Chemical predictive modelling to improve compound quality
JG Cumming, AM Davis, S Muresan, M Haeberlein, H Chen
Nature reviews Drug discovery 12 (12), 948-962, 2013
2142013
The total synthesis of swinholide A. Part 2: A stereocontrolled synthesis of a c1–c15 segment
I Paterson, JD Smith, RA Ward
Tetrahedron 51 (34), 9413-9436, 1995
1671995
Heterocyclic compounds useful as pharmaceutical agents
D Waterson, ESE Stokes, GR Brown, JG Cumming, NJ Newcombe, ...
US Patent 6,313,127, 2001
1042001
The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A
I Paterson, KS Yeung, RA Ward, JD Smith, JG Cuimming, S Lamboley
Tetrahedron 51 (34), 9467-9486, 1995
1031995
Total synthesis of swinholide A and hemiswinholide A
I Paterson, KS Yeung, RA Ward, JG Cumming, JD Smith
Journal of the American Chemical Society 116 (20), 9391-9392, 1994
931994
Subcutaneous calcium heparin versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: a multicentre prospective randomised trial.
MG Walker, JW Shaw, GJ Thomson, JG Cumming, ML Thomas
Br Med J (Clin Res Ed) 294 (6581), 1189-1192, 1987
761987
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
JG Cumming, CL McKenzie, SG Bowden, D Campbell, DJ Masters, ...
Bioorganic & medicinal chemistry letters 14 (21), 5389-5394, 2004
742004
Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity
J Burrows, A Cooper, J Cumming, T McInally, H Tucker
US Patent App. 10/276,430, 2004
702004
Synthesis and antiviral evaluation of enantiomeric 2′, 3′-dideoxy-and 2′, 3′-didehydro-2′, 3′-dideoxy-4′-thionucleosides
RJ Young, S Shaw-Ponter, JB Thomson, JA Miller, JG Cumming, ...
Bioorganic & Medicinal Chemistry Letters 5 (22), 2599-2604, 1995
681995
Studies in marine macrolide synthesis: boron and silicon-mediated coupling strategies for swinholide A
I Paterson, JG Cumming, JD Smith, RA Ward
Tetrahedron letters 35 (3), 441-444, 1994
671994
The total synthesis of swinholide A. Part 3: A stereocontrolled synthesis of (−)-pre-swinholide A.
I Paterson, RA Ward, JD Smith, JG Cumming, KS Yeung
Tetrahedron 51 (34), 9437-9466, 1995
651995
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas
JN Burrows, JG Cumming, SM Fillery, GA Hamlin, JA Hudson, RJ Jackson, ...
Bioorganic & medicinal chemistry letters 15 (1), 25-28, 2005
572005
Substituted anilino-quinazoline (or quinoline) compounds and use thereof
JG Cumming, A AB, Morgan, L Bockius LLP, RL Raymond, TN Truong
US Patent 6,593,333, 2003
572003
Dynamically resolved peri-substituted 2-formyl naphthamides: a new class of atropisomeric chiral auxiliary
J Clayden, C McCarthy, JG Cumming
Tetrahedron Letters 41 (18), 3279-3283, 2000
512000
A stereocontrolled synthesis of a C19-C32/C17-C30 Segment for swinholide A and misakinolide A, Cytotoxic dimeric macrolides from theonella swinhoei.
I Paterson, JG Cumming
Tetrahedron letters 33 (20), 2847-2850, 1992
501992
Total Synthesis of (-)-Preswinholide A
I Paterson, JD Smith, RA Ward, JG Cumming
Journal of the American Chemical Society 116 (6), 2615-2616, 1994
471994
Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (−)-pre-swinholide A
I Paterson, JG Cumming, JD Smith, RA Ward, KS Yeung
Tetrahedron letters 35 (20), 3405-3408, 1994
451994
Automated QSAR with a hierarchy of global and local models
DJ Wood, D Buttar, JG Cumming, AM Davis, U Norinder, SL Rodgers
Molecular informatics 30 (11‐12), 960-972, 2011
422011
Stereocontrolled assembly of tetrasubstituted tetrahydrofurans: a concise synthesis of virgatusin
T Akindele, SP Marsden, JG Cumming
Organic Letters 7 (17), 3685-3688, 2005
422005
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3, 3-diphenylpropyl)-piperidinyl phenylacetamides
JG Cumming, AE Cooper, K Grime, CJ Logan, S McLaughlin, J Oldfield, ...
Bioorganic & medicinal chemistry letters 15 (22), 5012-5015, 2005
312005
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