Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease B Ravikumar, C Vacher, Z Berger, JE Davies, S Luo, LG Oroz, F Scaravilli, ... Nature genetics 36 (6), 585-595, 2004 | 2797 | 2004 |
Regulation of mammalian autophagy in physiology and pathophysiology B Ravikumar, S Sarkar, JE Davies, M Futter, M Garcia-Arencibia, ... Physiological reviews 90 (4), 1383-1435, 2010 | 2078 | 2010 |
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein S Sarkar, JE Davies, Z Huang, A Tunnacliffe, DC Rubinsztein Journal of Biological Chemistry 282 (8), 5641-5652, 2007 | 1235 | 2007 |
Huntington's disease: from pathology and genetics to potential therapies S Imarisio, J Carmichael, V Korolchuk, C Chen, S Saiki, C Rose, ... Biochem. J 412, 191-209, 2008 | 499 | 2008 |
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases S Luo, C Vacher, JE Davies, DC Rubinsztein The Journal of cell biology 169 (4), 647-656, 2005 | 254 | 2005 |
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy JE Davies, S Sarkar, DC Rubinsztein Human molecular genetics 15 (1), 23, 2006 | 232 | 2006 |
Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice JE Davies, L Wang, L Garcia-Oroz, LJ Cook, C Vacher, DG O'Donovan, ... Nature medicine 11 (6), 672-677, 2005 | 168 | 2005 |
Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres C Trollet, SY Anvar, A Venema, IP Hargreaves, K Foster, A Vignaud, ... Human molecular genetics 19 (11), 2191-2207, 2010 | 93 | 2010 |
The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias J Davies, S Sarkar, D Rubinsztein BMC biochemistry 8 (Suppl 1), S2, 2007 | 80 | 2007 |
Cystamine suppresses polyalanine toxicity in a mouse model of oculopharyngeal muscular dystrophy JE Davies, C Rose, S Sarkar, DC Rubinsztein Science translational medicine 2 (34), 34ra40-34ra40, 2010 | 64 | 2010 |
Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation JE Davies, S Sarkar, DC Rubinsztein Human molecular genetics 17 (8), 1097, 2008 | 55 | 2008 |
Polyalanine and polyserine frameshift products in Huntington’s disease JE Davies, DC Rubinsztein Journal of medical genetics 43 (11), 893-896, 2006 | 55 | 2006 |
Autophagy in hypothalamic neurones of rats expressing a familial neurohypophysial diabetes insipidus transgene J Davies, D Murphy Journal of neuroendocrinology 14 (8), 629-637, 2002 | 55 | 2002 |
Endoplasmic reticulum derangement in hypothalamic neurons of rats expressing a familial neurohypophyseal diabetes insipidus mutant vasopressin transgene SL Si-Hoe, FM De Bree, M Nijenhuis, JE Davies, LMC Howell, H Tinley, ... The FASEB Journal 14 (12), 1680-1684, 2000 | 54 | 2000 |
Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene R Castino, J Davies, S Beaucourt, C Isidoro, D Murphy The FASEB journal 19 (8), 1021-1023, 2005 | 52 | 2005 |
Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion Z Berger, JE Davies, S Luo, MY Pasco, I Majoul, CJ O'Kane, ... Human molecular genetics 15 (3), 453, 2006 | 46 | 2006 |
Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder JE Davies, Z Berger, DC Rubinsztein The international journal of biochemistry & cell biology 38 (9), 1457-1462, 2006 | 38 | 2006 |
Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy JE Davies, DC Rubinsztein Human molecular genetics 20 (6), 1154, 2011 | 30 | 2011 |
Further delineation of the sequences required for the expression and physiological regulation of the vasopressin gene in transgenic rat hypothalamic magnocellular neurones J Davies, S Waller, Q Zeng, S Wells, D Murphy Journal of neuroendocrinology 15 (1), 42-50, 2003 | 27 | 2003 |
Towards a transgenic rat model of Familial Neurohypophysial Diabetes Insipidus JE Davies Bristol (United Kingdom): University of Bristol, 2002 | | 2002 |