| Biased and g protein-independent signaling of chemokine receptors A Steen, O Larsen, S Thiele, MM Rosenkilde Frontiers in immunology 5, 277, 2014 | 198 | 2014 |
| Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7 A Steen, S Thiele, D Guo, LS Hansen, TM Frimurer, MM Rosenkilde Journal of Biological Chemistry 288 (18), 12511-12521, 2013 | 75 | 2013 |
| Interaction of chemokines with their receptors–from initial chemokine binding to receptor activating steps S Thiele, M Marie Rosenkilde Current medicinal chemistry 21 (31), 3594-3614, 2014 | 62 | 2014 |
| Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding PC Jensen, S Thiele, T Ulven, TW Schwartz, MM Rosenkilde Journal of biological chemistry 283 (34), 23121-23128, 2008 | 57 | 2008 |
| Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach S Thiele, A Steen, PC Jensen, J Mokrosinski, TM Frimurer, ... Journal of Biological Chemistry 286 (43), 37543-37554, 2011 | 56 | 2011 |
| Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8 PC Jensen, R Nygaard, S Thiele, A Elder, G Zhu, R Kolbeck, S Ghosh, ... Molecular pharmacology 72 (2), 327-340, 2007 | 56 | 2007 |
| Determination of the binding mode for the cyclopentapeptide CXCR 4 antagonist FC 131 using a dual approach of ligand modifications and receptor mutagenesis S Thiele, J Mungalpara, A Steen, MM Rosenkilde, J Våbenø British Journal of Pharmacology 171 (23), 5313-5329, 2014 | 50 | 2014 |
| Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2 AJM Zweemer, J Bunnik, M Veenhuizen, F Miraglia, EB Lenselink, ... Molecular pharmacology 86 (4), 358-368, 2014 | 48 | 2014 |
| Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors S Thiele, M Malmgaard-Clausen, J Engel-Andreasen, A Steen, ... Journal of medicinal chemistry 55 (18), 8164-8177, 2012 | 38 | 2012 |
| Probing biased signaling in chemokine receptors RM Amarandi, GM Hjortø, MM Rosenkilde, S Karlshøj Methods in enzymology 570, 155-186, 2016 | 32 | 2016 |
| Rational design of conformationally constrained cyclopentapeptide antagonists for CXC chemokine receptor 4 (CXCR4) J Mungalpara, S Thiele, Ø Eriksen, J Eksteen, MM Rosenkilde, J Våbenø Journal of medicinal chemistry 55 (22), 10287-10291, 2012 | 31 | 2012 |
| Multistep Continuous‐Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure–Activity Relationships of CCR8 Ligands TP Petersen, S Mirsharghi, PC Rummel, S Thiele, MM Rosenkilde, ... Chemistry–A European Journal 19 (28), 9343-9350, 2013 | 29 | 2013 |
| Extracellular disulfide bridges serve different purposes in two homologous chemokine receptors, CCR1 and CCR5 PC Rummel, S Thiele, LS Hansen, TP Petersen, AH Sparre-Ulrich, ... Molecular Pharmacology 84 (3), 335-345, 2013 | 25 | 2013 |
| Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction E Soltysinska, S Thiele, SP Olesen, OE Osadchii Pflügers Archiv-European Journal of Physiology 462, 529-543, 2011 | 25 | 2011 |
| Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins A Göbel, AJ Browne, S Thiele, M Rauner, LC Hofbauer, TD Rachner Breast cancer research and treatment 154, 623-631, 2015 | 23 | 2015 |
| Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4) ZG Zachariassen, S Thiele, EA Berg, P Rasmussen, T Fossen, ... Bioorganic & Medicinal Chemistry 22 (17), 4759-4769, 2014 | 22 | 2014 |
| Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636) ZG Zachariassen, S Karlshøj, BE Haug, MM Rosenkilde, J Våbenø Journal of Medicinal Chemistry 58 (20), 8141-8153, 2015 | 20 | 2015 |
| Reversed binding of a small molecule ligand in homologous chemokine receptors–differential role of extracellular loop 2 PC Jensen, S Thiele, A Steen, A Elder, R Kolbeck, S Ghosh, TM Frimurer, ... British journal of pharmacology 166 (1), 258-275, 2012 | 20 | 2012 |
| Molecular requirements for inhibition of the chemokine receptor CCR8–probe‐dependent allosteric interactions PC Rummel, KN Arfelt, L Baumann, TJ Jenkins, S Thiele, HR Lüttichau, ... British journal of pharmacology 167 (6), 1206-1217, 2012 | 19 | 2012 |
| Role of conserved disulfide bridges and aromatic residues in extracellular loop 2 of chemokine receptor CCR8 for chemokine and small molecule binding L Barington, PC Rummel, M Lückmann, H Pihl, O Larsen, V Daugvilaite, ... Journal of Biological Chemistry 291 (31), 16208-16220, 2016 | 17 | 2016 |
