| A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ... Nature 583 (7816), 459-468, 2020 | 4351 | 2020 |
| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 614 | 2020 |
| A platform for the discovery of new macrolide antibiotics IB Seiple, Z Zhang, P Jakubec, A Langlois-Mercier, PM Wright, DT Hog, ... Nature 533 (7603), 338-345, 2016 | 330 | 2016 |
| Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ... Science 371 (6532), 926-931, 2021 | 297 | 2021 |
| Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition Y Katsuno, DS Meyer, Z Zhang, KM Shokat, RJ Akhurst, K Miyazono, ... Science signaling 12 (570), eaau8544, 2019 | 169 | 2019 |
| Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 TA Tummino, VV Rezelj, B Fischer, A Fischer, MJ O’Meara, B Monel, ... Science 373 (6554), 541-547, 2021 | 162 | 2021 |
| GTP-state-selective cyclic peptide ligands of K-Ras (G12D) block its interaction with Raf Z Zhang, R Gao, Q Hu, H Peacock, DM Peacock, S Dai, KM Shokat, ... ACS central science 6 (10), 1753-1761, 2020 | 83 | 2020 |
| Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras (G12S) Z Zhang, KZ Guiley, KM Shokat Nature Chemical Biology, 1-7, 2022 | 62 | 2022 |
| Stereocontrolled Synthesis of syn‐β‐Hydroxy‐α‐Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide IB Seiple, JAM Mercer, RJ Sussman, Z Zhang, AG Myers Angewandte Chemie International Edition 53 (18), 4642-4647, 2014 | 62 | 2014 |
| Chemoselective Covalent Modification of K-Ras (G12R) with a Small Molecule Electrophile Z Zhang, J Morstein, AK Ecker, KZ Guiley, KM Shokat Journal of the American Chemical Society 144 (35), 15916-15921, 2022 | 58 | 2022 |
| KRAS is vulnerable to reversible switch-II pocket engagement in cells JD Vasta, DM Peacock, Q Zheng, JA Walker, Z Zhang, CA Zimprich, ... Nature Chemical Biology 18 (6), 596-604, 2022 | 56 | 2022 |
| Enantioselective and Collective Syntheses of Xanthanolides Involving a Controllable Dyotropic Rearrangement of cis‐β‐Lactones W Ren, Y Bian, Z Zhang, H Shang, P Zhang, Y Chen, Z Yang, T Luo, ... Angewandte Chemie International Edition 51 (28), 6984-6988, 2012 | 48 | 2012 |
| A covalent inhibitor of K-Ras (G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy Z Zhang, PJ Rohweder, C Ongpipattanakul, K Basu, MF Bohn, EJ Dugan, ... Cancer Cell 40 (9), 1060-1069. e7, 2022 | 47 | 2022 |
| Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins Z Zhang, KM Shokat Angewandte Chemie 131 (45), 16460-16465, 2019 | 45 | 2019 |
| Diastereoselective Total Synthesis of (±)‐Schindilactone A, Part 3: The Final Phase and Completion WW Ren, ZX Chen, Q Xiao, Y Li, TW Sun, ZY Zhang, QD Ye, FK Meng, ... Chemistry–An Asian Journal 7 (10), 2341-2350, 2012 | 44 | 2012 |
| Tetracyclines modify translation by targeting key human rRNA substructures JD Mortison, M Schenone, JA Myers, Z Zhang, L Chen, C Ciarlo, E Comer, ... Cell chemical biology 25 (12), 1506-1518. e13, 2018 | 43 | 2018 |
| Brain-restricted mTOR inhibition with binary pharmacology Z Zhang, Q Fan, X Luo, K Lou, WA Weiss, KM Shokat Nature 609 (7928), 822-828, 2022 | 42 | 2022 |
| Rapid biomimetic total synthesis of (±)-rossinone B Z Zhang, J Chen, Z Yang, Y Tang Organic letters 12 (23), 5554-5557, 2010 | 34 | 2010 |
| Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B. 1.1. 7 variant AK Reuschl, LG Thorne, L Zuliani-Alvarez, M Bouhaddou, K Obernier, ... BioRxiv, 2021 | 33 | 2021 |
| State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides SA Dai, Q Hu, R Gao, EE Blythe, KK Touhara, H Peacock, Z Zhang, ... Cell, 2022 | 28 | 2022 |
Ian SeipleUC San FranciscoVerifierad e-postadress på ucsf.edu
