James DuHadaway
James DuHadaway
Laboratory Manager, LIMR
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Cited by
Cited by
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
AJ Muller, JB DuHadaway, PS Donover, E Sutanto-Ward, GC Prendergast
Nature medicine 11 (3), 312-319, 2005
Inhibition of indoleamine 2, 3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
DY Hou, AJ Muller, MD Sharma, J DuHadaway, T Banerjee, M Johnson, ...
Cancer research 67 (2), 792-801, 2007
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
A Bessede, M Gargaro, MT Pallotta, D Matino, G Servillo, C Brunacci, ...
Nature 511 (7508), 184-190, 2014
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2, 3-dioxygenase inhibitory compound D-1-methyl-tryptophan
R Metz, JB DuHadaway, U Kamasani, L Laury-Kleintop, AJ Muller, ...
Cancer research 67 (15), 7082-7087, 2007
Discovery of IDO1 inhibitors: from bench to bedside
GC Prendergast, WP Malachowski, JB DuHadaway, AJ Muller
Cancer research 77 (24), 6795-6811, 2017
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, ...
Cell death & disease 3 (11), e437-e437, 2012
IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
R Metz, S Rust, JB DuHadaway, MR Mautino, DH Munn, NN Vahanian, ...
Oncoimmunology 1 (9), 1460-1468, 2012
IDO is a nodal pathogenic driver of lung cancer and metastasis development
C Smith, MY Chang, KH Parker, DW Beury, JB DuHadaway, HE Flick, ...
Cancer discovery 2 (8), 722-735, 2012
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2, 3 dioxygenase
AJ Muller, MD Sharma, PR Chandler, JB DuHadaway, ME Everhart, ...
Proceedings of the National Academy of Sciences 105 (44), 17073-17078, 2008
Structure− activity study of brassinin derivatives as indoleamine 2, 3-dioxygenase inhibitors
P Gaspari, T Banerjee, WP Malachowski, AJ Muller, GC Prendergast, ...
Journal of medicinal chemistry 49 (2), 684-692, 2006
Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma
K Ge, J DuHadaway, W Du, M Herlyn, U Rodeck, GC Prendergast
Proceedings of the National Academy of Sciences 96 (17), 9689-9694, 1999
Indoleamine 2, 3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors
S Kumar, WP Malachowski, JB DuHadaway, JM LaLonde, PJ Carroll, ...
Journal of medicinal chemistry 51 (6), 1706-1718, 2008
A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2, 3-dioxygenase
T Banerjee, JB Duhadaway, P Gaspari, E Sutanto-Ward, DH Munn, ...
Oncogene 27 (20), 2851-2857, 2008
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
R Metz, C Smith, JB DuHadaway, P Chandler, B Baban, LMF Merlo, ...
International immunology 26 (7), 357-367, 2014
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2, 3-dioxygenase
S Kumar, D Jaller, B Patel, JM LaLonde, JB DuHadaway, ...
Journal of medicinal chemistry 51 (16), 4968-4977, 2008
Structural analysis of the human BIN1 gene: evidence for tissue-specific transcriptional regulation and alternate RNA splicing
R Wechsler-Reya, D Sakamuro, J Zhang, J Duhadaway, GC Prendergast
Journal of Biological Chemistry 272 (50), 31453-31458, 1997
Targeted Disruption of the Murine Bin1/Amphiphysin II Gene Does Not Disable Endocytosis but Results in Embryonic Cardiomyopathy with Aberrant Myofibril …
AJ Muller, JF Baker, JB DuHadaway, K Ge, G Farmer, PS Donover, ...
Molecular and cellular biology 23 (12), 4295-4306, 2003
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection
S Divanovic, NM Sawtell, A Trompette, JI Warning, A Dias, AM Cooper, ...
Journal of Infectious Diseases 205 (1), 152-161, 2012
Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity
K Ge, J Duhadaway, D Sakamuro, R Wechsler‐Reya, C Reynolds, ...
International journal of cancer 85 (3), 376-383, 2000
CCR5 governs DNA damage repair and breast cancer stem cell expansion
X Jiao, MA Velasco-Velazquez, M Wang, Z Li, H Rui, AR Peck, JE Korkola, ...
Cancer research 78 (7), 1657-1671, 2018
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