| Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization AK Jha, SCC Huang, A Sergushichev, V Lampropoulou, Y Ivanova, ... Immunity 42 (3), 419-430, 2015 | 1684 | 2015 |
| Functional genomics reveal that the serine synthesis pathway is essential in breast cancer R Possemato, KM Marks, YD Shaul, ME Pacold, D Kim, K Birsoy, ... Nature 476 (7360), 346-350, 2011 | 1639 | 2011 |
| Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer KC Patra, Q Wang, PT Bhaskar, L Miller, Z Wang, W Wheaton, N Chandel, ... Cancer cell 24 (2), 213-228, 2013 | 812 | 2013 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 770 | 2012 |
| Statistical coil model of the unfolded state: resolving the reconciliation problem AK Jha, A Colubri, KF Freed, TR Sosnick Proceedings of the National Academy of Sciences 102 (37), 13099-13104, 2005 | 358 | 2005 |
| Helix, sheet, and polyproline II frequencies and strong nearest neighbor effects in a restricted coil library AK Jha, A Colubri, MH Zaman, S Koide, TR Sosnick, KF Freed Biochemistry 44 (28), 9691-9702, 2005 | 211 | 2005 |
| Full-length human glutaminase in complex with an allosteric inhibitor B DeLaBarre, S Gross, C Fang, Y Gao, A Jha, F Jiang, J Song J, W Wei, ... Biochemistry 50 (50), 10764-10770, 2011 | 162 | 2011 |
| How the thymus designs antigen-specific and self-tolerant T cell receptor sequences A Košmrlj, AK Jha, ES Huseby, M Kardar, AK Chakraborty Proceedings of the National Academy of Sciences 105 (43), 16671-16676, 2008 | 136 | 2008 |
| Mimicking the folding pathway to improve homology-free protein structure prediction J DeBartolo, A Colubri, AK Jha, JE Fitzgerald, KF Freed, TR Sosnick Proceedings of the National Academy of Sciences 106 (10), 3734-3739, 2009 | 81 | 2009 |
| Minimalist representations and the importance of nearest neighbor effects in protein folding simulations A Colubri, AK Jha, M Shen, A Sali, RS Berry, TR Sosnick, KF Freed Journal of molecular biology 363 (4), 835-857, 2006 | 60 | 2006 |
| Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition DB Ulanet, K Couto, A Jha, S Choe, A Wang, HK Woo, M Steadman, ... PLoS One 9 (12), e115144, 2014 | 53 | 2014 |
| Reduced Cβ statistical potentials can outperform all‐atom potentials in decoy identification JE Fitzgerald, AK Jha, A Colubri, TR Sosnick, KF Freed Protein science 16 (10), 2123-2139, 2009 | 47 | 2009 |
| Solvation effect on conformations of 1, 2: Dimethoxyethane: Charge dependent nonlinear response in implicit solvent models AK Jha, KF Freed The Journal of chemical physics 128 (3), 034501, 2008 | 46 | 2008 |
| Small proteins fold through transition states with native-like topologies AD Pandit, A Jha, KF Freed, TR Sosnick Journal of molecular biology 361 (4), 755-770, 2006 | 42 | 2006 |
| Polypeptide motions are dominated by peptide group oscillations resulting from dihedral angle correlations between nearest neighbors JE Fitzgerald, AK Jha, TR Sosnick, KF Freed Biochemistry 46 (3), 669-682, 2007 | 35 | 2007 |
| Context and force field dependence of the loss of protein backbone entropy upon folding using realistic denatured and native state ensembles MC Baxa, EJ Haddadian, AK Jha, KF Freed, TR Sosnick Journal of the American Chemical Society 134 (38), 15929-15936, 2012 | 34 | 2012 |
| Benchmarking implicit solvent folding simulations of the amyloid β (10− 35) fragment A Kent, AK Jha, JE Fitzgerald, KF Freed The Journal of Physical Chemistry B 112 (19), 6175-6186, 2008 | 34 | 2008 |
| Automated Real-Space Refinement of Protein Structures Using a Realistic Backbone Move Set EJ Haddadian, H Gong, AK Jha, X Yang, J DeBartolo, JR Hinshaw, ... Biophysical Journal 101 (4), 899-909, 2011 | 28 | 2011 |
| Structural, dynamic properties of key residues in Aβ amyloidogenesis: Implications of an important role of nanosecond timescale dynamics KH Lim, GL Henderson, A Jha, M Louhivuori ChemBioChem 8 (11), 1251-1254, 2007 | 24 | 2007 |
| Local Backbone Preferences and Nearest‐Neighbor Effects in the Unfolded and Native States J DeBartolo, A Jha, KF Freed, TR Sosnick Protein and Peptide Folding, Misfolding, and Non‐Folding, 79-98, 2012 | 17 | 2012 |
Karl F. FreedProfessor of Chemistry, Emeritis, U of ChicagoVerified email at uchicago.edu
