| Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B JF Tien, NT Umbreit, DR Gestaut, AD Franck, J Cooper, L Wordeman, ... Journal of Cell Biology 189 (4), 713-723, 2010 | 257 | 2010 |
| CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion JF Tien, A Mazloomian, SWG Cheng, CS Hughes, CCT Chow, LT Canapi, ... Nucleic acids research 45 (11), 6698-6716, 2017 | 155 | 2017 |
| The Ndc80 kinetochore complex directly modulates microtubule dynamics NT Umbreit, DR Gestaut, JF Tien, BS Vollmar, T Gonen, CL Asbury, ... Proceedings of the National Academy of Sciences 109 (40), 16113-16118, 2012 | 147 | 2012 |
| Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II SWG Cheng, MA Kuzyk, A Moradian, TA Ichu, VCD Chang, JF Tien, ... Molecular and cellular biology, 2012 | 118 | 2012 |
| Kinetochores’ gripping feat: conformational wave or biased diffusion? CL Asbury, JF Tien, TN Davis Trends in cell biology 21 (1), 38-46, 2011 | 74 | 2011 |
| Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation NT Umbreit, MP Miller, JF Tien, J Cattin Ortolá, L Gui, KK Lee, S Biggins, ... Nature communications 5 (1), 4951, 2014 | 70 | 2014 |
| Coupling Unbiased Mutagenesis to High-throughput DNA Sequencing Uncovers Functional Domains in the Ndc80 Kinetochore Protein of Saccharomyces cerevisiae JF Tien, KK Fong, NT Umbreit, C Payen, A Zelter, CL Asbury, MJ Dunham, ... Genetics 195 (1), 159-170, 2013 | 31 | 2013 |
| Kinetochore Biorientation in Saccharomyces cerevisiae Requires a Tightly Folded Conformation of the Ndc80 Complex JF Tien, NT Umbreit, A Zelter, M Riffle, MR Hoopmann, RS Johnson, ... Genetics 198 (4), 1483-1493, 2014 | 30 | 2014 |
| Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora BJ Cell Biol. 189: 713–723 JF Tien, NT Umbreit, DR Gestaut, AD Franck, J Cooper, L Wordeman, ... | 5 | 2010 |
| VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro LJ Laine, JHE Mäki-Jouppila, E Kutvonen, P Tiikkainen, TKM Nyholm, ... Oncoscience 8, 134, 2021 | 2 | 2021 |
| Regulation of Ndc80-based microtubule attachments by the central kinetochore Mis12/MIND complex suggests a folding-based molecular mechanism EA Scarborough, EM Kudalkar, N Umbreit, J Tien, CL Asbury, E Muller, ... MOLECULAR BIOLOGY OF THE CELL 26, 2015 | | 2015 |
| Linker Scanning Mutagenesis of Yeast Microtubule Nucleating Components Spc97 and Spc98. K Fong, J Tien, C Payen, A Zelter, B Graczyk, M Dunham, T Davis MOLECULAR BIOLOGY OF THE CELL 25, 2014 | | 2014 |
| VTT-006, a novel anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro L Laine, J Maki-Jouppila, E Kutvonen, P Tiikkainen, T Nyholm, J Tien, ... MOLECULAR BIOLOGY OF THE CELL 25, 2014 | | 2014 |
| Biophysical mechanisms of the kinetochore-microtubule interface and its regulation during mitosis N Umbreit | | 2014 |
| Linker scanning mutagenesis of yeast microtubule nucleating proteins Spc97 and Spc98 reveals essential functional and structural protein regions K Fong, J Tien, C Payen, B Graczyk, A Zelter, M Dunham, T Davis MOLECULAR BIOLOGY OF THE CELL 24, 2013 | | 2013 |
| Coupling unbiased mutagenesis to high-throughput sequencing uncovers functional domains in the yeast and human Ndc80 kinetochore proteins J Tien, K Fong, N Umbreit, C Payen, A Zelter, C Asbury, M Dunham, ... MOLECULAR BIOLOGY OF THE CELL 24, 2013 | | 2013 |
| Linker-scanning mutagenesis of the Ndc80 kinetochore protein J Tien, K Fong, N Umbreit, C Payen, A Zelter, M Dunham, T Davis MOLECULAR BIOLOGY OF THE CELL 23, 2012 | | 2012 |
| Linker scanning mutagenesis of yeast microtubule nucleating proteins Spc97 and Spc98 K Fong, J Tien, C Payen, B Graczyk, A Zelter, M Dunham, T Davis MOLECULAR BIOLOGY OF THE CELL 23, 2012 | | 2012 |
| The human Ndc80 complex is a microtubule rescue factor regulated by Aurora B kinase. D Gestaut, N Umbreit, J Tien, B Vollmar, T Gonen, C Asbury, T Davis MOLECULAR BIOLOGY OF THE CELL 22, 2011 | | 2011 |
| The CrkRS/CDK12 kinase is activated by a novel isoform of Cyclin K and phosphorylates the C‐terminal domain of RNA Pol II GB Morin, MA Kuzyk, JF Tien, E Schaeffer, SWG Cheng The FASEB Journal 23, 492.3-492.3, 2009 | | 2009 |
Neil T. UmbreitDana-Farber Cancer InstituteVerified email at dfci.harvard.edu
