| G proteins JR Hepler, AG Gilman Trends in biochemical sciences 17 (10), 383-387, 1992 | 1567 | 1992 |
| Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq AV Smrcka, JR Hepler, KO Brown, PC Sternweis Science 251 (4995), 804-807, 1991 | 1154 | 1991 |
| Cellular regulation of RGS proteins: modulators and integrators of G protein signaling S Hollinger, JR Hepler Pharmacological reviews 54 (3), 527-559, 2002 | 876 | 2002 |
| RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase Cβ by γ-thio-GTP-Gqα JR Hepler, DM Berman, AG Gilman, T Kozasa Proceedings of the National Academy of Sciences 94 (2), 428-432, 1997 | 487 | 1997 |
| RGS2/G0S8 is a selective inhibitor of Gqα function SP Heximer, N Watson, ME Linder, KJ Blumer, JR Hepler Proceedings of the National Academy of Sciences 94 (26), 14389-14393, 1997 | 451 | 1997 |
| Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. R Taussig, WJ Tang, JR Hepler, AG Gilman Journal of Biological Chemistry 269 (8), 6093-6100, 1994 | 444 | 1994 |
| Lipid modifications of G proteins: alpha subunits are palmitoylated. ME Linder, P Middleton, JR Hepler, R Taussig, AG Gilman, SM Mumby Proceedings of the National Academy of Sciences 90 (8), 3675-3679, 1993 | 442 | 1993 |
| Cell signalling diversity of the Gqα family of heterotrimeric G proteins KB Hubbard, JR Hepler Cellular signalling 18 (2), 135-150, 2006 | 351 | 2006 |
| Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits JR Hepler, T Kozasa, AV Smrcka, MI Simon, SG Rhee, PC Sternweis, ... Journal of Biological Chemistry 268 (19), 14367-14375, 1993 | 337 | 1993 |
| Emerging roles for RGS proteins in cell signalling JR Hepler Trends in pharmacological sciences 20 (9), 376-382, 1999 | 329 | 1999 |
| RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11α signaling LS Bernstein, S Ramineni, C Hague, W Cladman, P Chidiac, AI Levey, ... Journal of Biological Chemistry 279 (20), 21248-21256, 2004 | 274 | 2004 |
| Organization of G proteins and adenylyl cyclase at the plasma membrane C Huang, JR Hepler, LT Chen, AG Gilman, RGW Anderson, SM Mumby Molecular biology of the cell 8 (12), 2365-2378, 1997 | 261 | 1997 |
| Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes SD Sorensen, O Nicole, RD Peavy, LM Montoya, CJ Lee, TJ Murphy, ... Molecular pharmacology 64 (5), 1199-1209, 2003 | 241 | 2003 |
| Characterization of antisera to glutamate and aspartate. JR Hepler, CS Toomim, KD McCarthy, F Conti, G Battaglia, A Rustioni, ... Journal of Histochemistry & Cytochemistry 36 (1), 13-22, 1988 | 232 | 1988 |
| The concise guide to pharmacology 2021/22: Introduction and other protein targets SPH Alexander, E Kelly, A Mathie, JA Peters, EL Veale, JF Armstrong, ... British journal of pharmacology 178, S1-S26, 2021 | 231 | 2021 |
| Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a … JR Hepler, HS Earp, TK Harden Journal of Biological Chemistry 263 (16), 7610-7619, 1988 | 212 | 1988 |
| Epidermal growth factor stimulates the rapid accumulation of inositol (1, 4, 5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. JR Hepler, N Nakahata, TW Lovenberg, J DiGuiseppi, B Herman, ... Journal of Biological Chemistry 262 (7), 2951-2956, 1987 | 211 | 1987 |
| RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory SE LEE, SB SIMONS, SA HELDT, Z MEILAN, JP SCHROEDER, ... Proceedings of the National Academy of Sciences of the United States of …, 2010 | 208 | 2010 |
| G protein selectivity is a determinant of RGS2 function SP Heximer, SP Srinivasa, LS Bernstein, JL Bernard, ME Linder, ... Journal of Biological Chemistry 274 (48), 34253-34259, 1999 | 206 | 1999 |
| Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells C Huang, JR Hepler, AG Gilman, SM Mumby Proceedings of the National Academy of Sciences 94 (12), 6159-6163, 1997 | 204 | 1997 |
Serena DudekNational Institute of Environmental Health Sciences, NIHVerified email at niehs.nih.gov
