Li Pang
Li Pang
National Center for Toxicological Research US FDA
Verifierad e-postadress på fda.hhs.gov
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Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing–induced congestive heart failure
D Li, K Shinagawa, L Pang, TK Leung, S Cardin, Z Wang, S Nattel
Circulation 104 (21), 2608-2614, 2001
International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment
K Blinova, Q Dang, D Millard, G Smith, J Pierson, L Guo, M Brock, HR Lu, ...
Cell reports 24 (13), 3582-3592, 2018
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias
K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ...
Toxicological Sciences 155 (1), 234-247, 2017
Tissue‐specific expression of two human Cav1.2 isoforms under the control of distinct 5′ flanking regulatory elements
L Pang, G Koren, Z Wang, S Nattel
FEBS letters 546 (2-3), 349-354, 2003
Evaluation of batch variations in induced pluripotent stem cell-derived human cardiomyocytes from 2 major suppliers
J Huo, A Kamalakar, X Yang, B Word, N Stockbridge, B Lyn-Cook, L Pang
Toxicological Sciences 156 (1), 25-38, 2017
Characterization of a putative insulin-responsive element and its binding protein (s) in rat angiotensinogen gene promoter: regulation by glucose and insulin
X Chen, SL Zhang, L Pang, JG Filep, SS Tang, JR Ingelfinger, JSD Chan
Endocrinology 142 (6), 2577-2585, 2001
Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy
SW Rhee, JR Stimers, W Wang, L Pang
Journal of Pharmacology and Experimental Therapeutics 329 (2), 775-782, 2009
Reversal of microRNA dysregulation in an animal model of pulmonary hypertension
IB Gubrij, AK Pangle, L Pang, LG Johnson
PloS one 11 (1), e0147827, 2016
Workshop report: FDA workshop on improving cardiotoxicity assessment with human-relevant platforms
L Pang, P Sager, X Yang, H Shi, F Sannajust, M Brock, JC Wu, ...
Circulation research 125 (9), 855-867, 2019
Sex-related differences in drug-induced QT prolongation and torsades de pointes: a new model system with human iPSC-CMs
J Huo, F Wei, C Cai, B Lyn-Cook, L Pang
Toxicological Sciences 167 (2), 360-374, 2019
ATP-binding cassette genes genotype and expression: a potential association with pancreatic cancer development and chemoresistance?
L Pang, B Word, J Xu, H Wang, G Hammons, SM Huang, B Lyn-Cook
Gastroenterology research and practice 2014, 2014
Vascular-Specific Increase in Exon 1b-Encoded CaV1.2 Channels in Spontaneously Hypertensive Rats
W Wang, N Saada, B Dai, L Pang, P Palade
American journal of hypertension 19 (8), 823-831, 2006
MicroRNA-mediated maturation of human pluripotent stem cell-derived cardiomyocytes: Towards a better model for cardiotoxicity?
MC White, L Pang, X Yang
Food and Chemical Toxicology 98, 17-24, 2016
Characterization of the cardiac KCNE1 gene promoter
Z Mustapha, L Pang, S Nattel
Cardiovascular research 73 (1), 82-91, 2007
Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations
G Gintant, EP Kaushik, T Feaster, S Stoelzle-Feix, Y Kanda, T Osada, ...
Regulatory toxicology and pharmacology 117, 104756, 2020
Toxicity testing in the era of induced pluripotent stem cells: A perspective regarding the use of patient-specific induced pluripotent stem cell–derived cardiomyocytes for …
L Pang
Current Opinion in Toxicology 23, 50-55, 2020
Angiotensin II upregulates Cav1. 2 protein expression in cultured arteries via endothelial H2O2 production
W Wang, L Pang, P Palade
Journal of vascular research 48 (1), 67-78, 2011
Angiotensin II causes endothelial-dependent increase in expression of CaV1. 2 protein in cultured arteries
W Wang, L Pang, P Palade
European journal of pharmacology 599 (1-3), 117-120, 2008
Effects of electrical stimulation on hiPSC-CM responses to classic ion channel blockers
F Wei, M Pourrier, DG Strauss, N Stockbridge, L Pang
Toxicological Sciences 174 (2), 254-265, 2020
High-conductance, Ca2+-activated K+ channels: altered expression profiles in aging and cardiovascular disease
L Pang, NJ Rusch
Molecular Interventions 9 (5), 230, 2009
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Artiklar 1–20