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Francesco De Chiara
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Urea cycle dysregulation in non-alcoholic fatty liver disease
F De Chiara, S Heebøll, G Marrone, C Montoliu, S Hamilton-Dutoit, ...
Journal of hepatology 69 (4), 905-915, 2018
1572018
Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension
R Jalan, F De Chiara, V Balasubramaniyan, F Andreola, V Khetan, ...
Journal of hepatology 64 (4), 823-833, 2016
1292016
Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-α
MA Ortega, X Fernández-Garibay, AG Castaño, F De Chiara, ...
Lab on a Chip 19 (15), 2568-2580, 2019
1112019
Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure
R Garcia-Martinez, F Andreola, G Mehta, K Poulton, M Oria, M Jover, ...
Journal of hepatology 62 (4), 799-806, 2015
892015
Ammonia scavenging prevents progression of fibrosis in experimental nonalcoholic fatty liver disease
F De Chiara, KL Thomsen, A Habtesion, H Jones, N Davies, ...
Hepatology 71 (3), 874-892, 2020
782020
Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis
KL Thomsen, F De Chiara, K Rombouts, H Vilstrup, F Andreola, ...
Medical hypotheses 113, 91-97, 2018
432018
New perspectives for natural antimicrobial peptides: application as antinflammatory drugs in a murine model
R Capparelli, F De Chiara, N Nocerino, RC Montella, M Iannaccone, ...
BMC immunology 13, 1-14, 2012
382012
Recombinant alkaline phosphatase prevents acute on chronic liver failure
C Engelmann, D Adebayo, M Oria, F De Chiara, S Novelli, A Habtesion, ...
Scientific Reports 10 (1), 389, 2020
362020
Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease
A Hadjihambi, F De Chiara, PS Hosford, A Habtetion, A Karagiannis, ...
Hepatology 65 (4), 1306-1318, 2017
332017
High protein diet and metabolic plasticity in non-alcoholic fatty liver disease: myths and truths
F De Chiara, C Ureta Checcllo, J Ramon Azcon
Nutrients 11 (12), 2985, 2019
322019
The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis
R Capparelli, F De Chiara, A Di Matteo, C Medaglia, D Iannelli
Genes & Immunity 14 (8), 504-511, 2013
312013
Exogenous liposomal ceramide-C6 ameliorates lipidomic profile, energy homeostasis, and anti-oxidant systems in NASH
F Zanieri, A Levi, D Montefusco, L Longato, F De Chiara, L Frenguelli, ...
Cells 9 (5), 1237, 2020
142020
Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
R Jalan, RP Mookerjee, K Rombouts, F Andreola, F De Chiara, ...
US Patent 10,039,735, 2018
142018
The adenosine monophosphate–activated protein kinase—Vacuolar adenosine triphosphatase–pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells
G Marrone, F De Chiara, K Böttcher, A Levi, D Dhar, L Longato, G Mazza, ...
Hepatology 68 (3), 1140-1153, 2018
132018
Early increase in ammonia is a feature of non-alcoholic fatty liver disease and the ammonia lowering drug, ornithine phenylacetate (OCR002) prevents progression of fibrosis in …
F De Chiara, A Habtension, N Davies, F Andreola, K Rombouts, N Arias, ...
Journal of Clinical and Experimental Hepatology 7, S73-S74, 2017
102017
Role of ammonia in NAFLD: an unusual suspect
KL Thomsen, PL Eriksen, AJC Kerbert, F De Chiara, R Jalan, H Vilstrup
JHEP Reports, 100780, 2023
92023
Collagen-Tannic Acid Spheroids for β-Cell Encapsulation Fabricated Using a 3D Bioprinter
CF Laura, DC Francesco, RC Júlia, C Jordi, M Elena, G Amelie Luise, ...
Advanced Material Technologies 7, 2101696, 2022
92022
The synergy between organ-on-a-chip and artificial intelligence for the study of NAFLD: from basic science to clinical research
F De Chiara, A Ferret-Miñana, J Ramón-Azcón
Biomedicines 9 (3), 248, 2021
92021
Ornithine transcarbamylase gene expression and hepatic urea nitrogen handling are reduced in models of NAFLD and recovers with dietary modulation and reducing bacterial …
KL Thomsen, F De Chiara, F Andreola, K Rombouts, J MacNaughtan, ...
HEPATOLOGY 62, 657A-657A, 2015
92015
Organs‐on‐Chips: Trends and Challenges in Advanced Systems Integration
S Mughal, GA López‐Muñoz, JM Fernández‐Costa, A Cortés‐Reséndiz, ...
Advanced Materials Interfaces 9 (33), 2201618, 2022
82022
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