| The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor, ... Molecular cell 12 (6), 1427-1437, 2003 | 289 | 2003 |
| Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides HE Blackwell, JD Sadowsky, RJ Howard, JN Sampson, JA Chao, ... The Journal of organic chemistry 66 (16), 5291-5302, 2001 | 280 | 2001 |
| Shared structural mechanisms of general anaesthetics and benzodiazepines JJ Kim, A Gharpure, J Teng, Y Zhuang, RJ Howard, S Zhu, CM Noviello, ... Nature 585 (7824), 303-308, 2020 | 201 | 2020 |
| Structural insight into KCNQ (Kv7) channel assembly and channelopathy RJ Howard, KA Clark, JM Holton, DL Minor Neuron 53 (5), 663-675, 2007 | 179 | 2007 |
| Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel L Sauguet, RJ Howard, L Malherbe, US Lee, PJ Corringer, R Adron Harris, ... Nature communications 4 (1), 1697, 2013 | 147 | 2013 |
| Structural basis for alcohol modulation of a pentameric ligand-gated ion channel RJ Howard, S Murail, KE Ondricek, PJ Corringer, E Lindahl, JR Trudell, ... Proceedings of the National Academy of Sciences 108 (29), 12149-12154, 2011 | 120 | 2011 |
| Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor A Gharpure, J Teng, Y Zhuang, CM Noviello, RM Walsh, R Cabuco, ... Neuron 104 (3), 501-511. e6, 2019 | 119 | 2019 |
| Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC) R Spurny, B Billen, RJ Howard, M Brams, S Debaveye, KL Price, ... Journal of Biological Chemistry 288 (12), 8355-8364, 2013 | 95 | 2013 |
| Alcohol‐binding sites in distinct brain proteins: the quest for atomic level resolution RJ Howard, PA Slesinger, DL Davies, J Das, JR Trudell, RA Harris Alcoholism: Clinical and Experimental Research 35 (9), 1561-1573, 2011 | 65 | 2011 |
| Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics RJ Howard, JR Trudell, RA Harris Pharmacological reviews 66 (2), 396-412, 2014 | 61 | 2014 |
| Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples A Alekseenko, D Barrett, Y Pareja-Sanchez, RJ Howard, E Strandback, ... Scientific reports 11 (1), 1820, 2021 | 59 | 2021 |
| Molecular mechanism for the dual alcohol modulation of Cys-loop receptors S Murail, RJ Howard, T Broemstrup, EJ Bertaccini, RA Harris, JR Trudell, ... Public Library of Science 8 (10), e1002710, 2012 | 48 | 2012 |
| Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels Z Fourati, RJ Howard, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ... Cell reports 23 (4), 993-1004, 2018 | 32 | 2018 |
| Sharing data from molecular simulations M Abraham, R Apostolov, J Barnoud, P Bauer, C Blau, AMJJ Bonvin, ... Journal of chemical information and modeling 59 (10), 4093-4099, 2019 | 29 | 2019 |
| Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra-and intersubunit sites T Brömstrup, RJ Howard, JR Trudell, RA Harris, E Lindahl Structure 21 (8), 1307-1316, 2013 | 25 | 2013 |
| Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity SA Heusser, M Lycksell, X Wang, SE McComas, RJ Howard, E Lindahl Proceedings of the National Academy of Sciences 115 (42), 10672-10677, 2018 | 24 | 2018 |
| Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels SA Heusser, RJ Howard, CM Borghese, MA Cullins, T Broemstrup, ... Molecular pharmacology 84 (5), 670-678, 2013 | 22 | 2013 |
| The TM2 6′ position of GABAA receptors mediates alcohol inhibition WD Johnson, RJ Howard, JR Trudell, RA Harris Journal of Pharmacology and Experimental Therapeutics 340 (2), 445-456, 2012 | 21 | 2012 |
| Elephants in the dark: Insights and incongruities in pentameric ligand-gated ion channel models RJ Howard Journal of Molecular Biology 433 (17), 167128, 2021 | 16 | 2021 |
| Molecular dynamics simulations of ion channels V Carnevale, L Delemotte, RJ Howard Trends in Biochemical Sciences 46 (7), 621-622, 2021 | 16 | 2021 |
Erik LindahlProfessor of Biophysics, Stockholm University & KTH, Science for Life LaboratoryVerified email at dbb.su.se
