Rebecca J Howard
Rebecca J Howard
Senior Researcher, Stockholm University
Verified email at - Homepage
Cited by
Cited by
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor, ...
Molecular cell 12 (6), 1427-1437, 2003
Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides
HE Blackwell, JD Sadowsky, RJ Howard, JN Sampson, JA Chao, ...
The Journal of organic chemistry 66 (16), 5291-5302, 2001
Shared structural mechanisms of general anaesthetics and benzodiazepines
JJ Kim, A Gharpure, J Teng, Y Zhuang, RJ Howard, S Zhu, CM Noviello, ...
Nature 585 (7824), 303-308, 2020
Structural insight into KCNQ (Kv7) channel assembly and channelopathy
RJ Howard, KA Clark, JM Holton, DL Minor
Neuron 53 (5), 663-675, 2007
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel
L Sauguet, RJ Howard, L Malherbe, US Lee, PJ Corringer, R Adron Harris, ...
Nature communications 4 (1), 1697, 2013
Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor
A Gharpure, J Teng, Y Zhuang, CM Noviello, RM Walsh, R Cabuco, ...
Neuron 104 (3), 501-511. e6, 2019
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
RJ Howard, S Murail, KE Ondricek, PJ Corringer, E Lindahl, JR Trudell, ...
Proceedings of the National Academy of Sciences 108 (29), 12149-12154, 2011
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC)
R Spurny, B Billen, RJ Howard, M Brams, S Debaveye, KL Price, ...
Journal of Biological Chemistry 288 (12), 8355-8364, 2013
Alcohol‐binding sites in distinct brain proteins: the quest for atomic level resolution
RJ Howard, PA Slesinger, DL Davies, J Das, JR Trudell, RA Harris
Alcoholism: Clinical and Experimental Research 35 (9), 1561-1573, 2011
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples
A Alekseenko, D Barrett, Y Pareja-Sanchez, RJ Howard, E Strandback, ...
Scientific reports 11 (1), 1820, 2021
Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics
RJ Howard, JR Trudell, RA Harris
Pharmacological reviews 66 (2), 396-412, 2014
Molecular mechanism for the dual alcohol modulation of Cys-loop receptors
S Murail, RJ Howard, T Broemstrup, EJ Bertaccini, RA Harris, JR Trudell, ...
Public Library of Science 8 (10), e1002710, 2012
Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities
S Zhu, A Sridhar, J Teng, RJ Howard, E Lindahl, RE Hibbs
Nature communications 13 (1), 4582, 2022
Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels
Z Fourati, RJ Howard, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ...
Cell reports 23 (4), 993-1004, 2018
Sharing data from molecular simulations
M Abraham, R Apostolov, J Barnoud, P Bauer, C Blau, AMJJ Bonvin, ...
Journal of chemical information and modeling 59 (10), 4093-4099, 2019
Elephants in the dark: Insights and incongruities in pentameric ligand-gated ion channel models
RJ Howard
Journal of Molecular Biology 433 (17), 167128, 2021
Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
SA Heusser, M Lycksell, X Wang, SE McComas, RJ Howard, E Lindahl
Proceedings of the National Academy of Sciences 115 (42), 10672-10677, 2018
Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra-and intersubunit sites
T Br÷mstrup, RJ Howard, JR Trudell, RA Harris, E Lindahl
Structure 21 (8), 1307-1316, 2013
Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels
SA Heusser, RJ Howard, CM Borghese, MA Cullins, T Broemstrup, ...
Molecular pharmacology 84 (5), 670-678, 2013
Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium
A Mehregan, S PÚrez-Conesa, Y Zhuang, A Elbahnsi, D Pasini, E Lindahl, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1864 (10), 183994, 2022
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