SERGEY SHIRYAEV
SERGEY SHIRYAEV
Staff Scientist, SBP Medical Discovery Institute
Verified email at sbpdiscovery.org
Title
Cited by
Cited by
Year
Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold
AE Aleshin, SA Shiryaev, AY Strongin, RC Liddington
Protein science 16 (5), 795-806, 2007
2072007
Substrate cleavage analysis of furin and related proprotein convertases: a comparative study
AG Remacle, SA Shiryaev, ES Oh, P Cieplak, A Srinivasan, G Wei, ...
Journal of Biological Chemistry 283 (30), 20897-20906, 2008
1292008
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
S D'Alessio, G Ferrari, K Cinnante, W Scheerer, AC Galloway, DF Roses, ...
Journal of Biological Chemistry 283 (1), 87-99, 2008
1202008
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer
M Ouyang, H Huang, NC Shaner, AG Remacle, SA Shiryaev, AY Strongin, ...
Cancer research 70 (6), 2204-2212, 2010
1162010
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis
SA Shiryaev, AY Savinov, P Cieplak, BI Ratnikov, K Motamedchaboki, ...
PloS one 4 (3), e4952, 2009
1112009
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth
AG Remacle, VS Golubkov, SA Shiryaev, R Dahl, JL Stebbins, ...
Cancer research 72 (9), 2339-2349, 2012
1092012
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus
PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ...
Assay and drug development technologies 5 (6), 737-750, 2007
1082007
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens
SA Shiryaev, AG Remacle, BI Ratnikov, NA Nelson, AY Savinov, G Wei, ...
Journal of Biological Chemistry 282 (29), 20847-20853, 2007
1062007
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
SA Shiryaev, BI Ratnikov, AV Chekanov, S Sikora, DV Rozanov, A Godzik, ...
Biochemical Journal 393 (2), 503-511, 2006
1042006
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
SA Shiryaev, P Mesci, A Pinto, I Fernandes, N Sheets, S Shresta, C Farhy, ...
Scientific reports 7 (1), 1-9, 2017
992017
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus
SA Shiryaev, AV Chernov, AE Aleshin, TN Shiryaeva, AY Strongin
The Journal of general virology 90 (Pt 9), 2081, 2009
922009
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration
Y Kim, AG Remacle, AV Chernov, H Liu, I Shubayev, C Lai, J Dolkas, ...
PloS one 7 (3), e33664, 2012
882012
Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses
SA Shiryaev, IA Kozlov, BI Ratnikov, JW Smith, M Lebl, AY Strongin
Biochemical Journal 401 (3), 743-752, 2007
792007
Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
SA Shiryaev, C Farhy, A Pinto, CT Huang, N Simonetti, AE Ngono, ...
Antiviral research 143, 218-229, 2017
772017
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry
S Yang, M Xu, EM Lee, K Gorshkov, SA Shiryaev, S He, W Sun, ...
Cell discovery 4 (1), 1-14, 2018
672018
Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
S Sidique, SA Shiryaev, BI Ratnikov, A Herath, Y Su, AY Strongin, ...
Bioorganic & medicinal chemistry letters 19 (19), 5773-5777, 2009
562009
Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis
SA Shiryaev, BI Ratnikov, AE Aleshin, IA Kozlov, NA Nelson, M Lebl, ...
Journal of virology 81 (9), 4501-4509, 2007
502007
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis
SA Shiryaev, AG Remacle, AY Savinov, AV Chernov, P Cieplak, ...
Journal of Biological Chemistry 284 (44), 30615-30626, 2009
472009
Blocking Zika virus vertical transmission
P Mesci, A Macia, SM Moore, SA Shiryaev, A Pinto, CT Huang, L Tejwani, ...
Scientific reports 8 (1), 1-13, 2018
462018
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
H Liu, SA Shiryaev, AV Chernov, Y Kim, I Shubayev, AG Remacle, ...
Journal of neuroinflammation 9 (1), 1-18, 2012
462012
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