Staff Scientist, SBP Medical Discovery Institute
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Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold
AE Aleshin, SA Shiryaev, AY Strongin, RC Liddington
Protein science 16 (5), 795-806, 2007
Substrate cleavage analysis of furin and related proprotein convertases: a comparative study
AG Remacle, SA Shiryaev, ES Oh, P Cieplak, A Srinivasan, G Wei, ...
Journal of Biological Chemistry 283 (30), 20897-20906, 2008
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism
S D'Alessio, G Ferrari, K Cinnante, W Scheerer, AC Galloway, DF Roses, ...
Journal of Biological Chemistry 283 (1), 87-99, 2008
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer
M Ouyang, H Huang, NC Shaner, AG Remacle, SA Shiryaev, AY Strongin, ...
Cancer research 70 (6), 2204-2212, 2010
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis
SA Shiryaev, AY Savinov, P Cieplak, BI Ratnikov, K Motamedchaboki, ...
PloS one 4 (3), e4952, 2009
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth
AG Remacle, VS Golubkov, SA Shiryaev, R Dahl, JL Stebbins, ...
Cancer research 72 (9), 2339-2349, 2012
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus
PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ...
Assay and drug development technologies 5 (6), 737-750, 2007
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens
SA Shiryaev, AG Remacle, BI Ratnikov, NA Nelson, AY Savinov, G Wei, ...
Journal of Biological Chemistry 282 (29), 20847-20853, 2007
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase
SA Shiryaev, BI Ratnikov, AV Chekanov, S Sikora, DV Rozanov, A Godzik, ...
Biochemical Journal 393 (2), 503-511, 2006
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
SA Shiryaev, P Mesci, A Pinto, I Fernandes, N Sheets, S Shresta, C Farhy, ...
Scientific reports 7 (1), 1-9, 2017
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus
SA Shiryaev, AV Chernov, AE Aleshin, TN Shiryaeva, AY Strongin
The Journal of general virology 90 (Pt 9), 2081, 2009
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration
Y Kim, AG Remacle, AV Chernov, H Liu, I Shubayev, C Lai, J Dolkas, ...
PloS one 7 (3), e33664, 2012
Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses
SA Shiryaev, IA Kozlov, BI Ratnikov, JW Smith, M Lebl, AY Strongin
Biochemical Journal 401 (3), 743-752, 2007
Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
SA Shiryaev, C Farhy, A Pinto, CT Huang, N Simonetti, AE Ngono, ...
Antiviral research 143, 218-229, 2017
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry
S Yang, M Xu, EM Lee, K Gorshkov, SA Shiryaev, S He, W Sun, ...
Cell discovery 4 (1), 1-14, 2018
Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
S Sidique, SA Shiryaev, BI Ratnikov, A Herath, Y Su, AY Strongin, ...
Bioorganic & medicinal chemistry letters 19 (19), 5773-5777, 2009
Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis
SA Shiryaev, BI Ratnikov, AE Aleshin, IA Kozlov, NA Nelson, M Lebl, ...
Journal of virology 81 (9), 4501-4509, 2007
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis
SA Shiryaev, AG Remacle, AY Savinov, AV Chernov, P Cieplak, ...
Journal of Biological Chemistry 284 (44), 30615-30626, 2009
Blocking Zika virus vertical transmission
P Mesci, A Macia, SM Moore, SA Shiryaev, A Pinto, CT Huang, L Tejwani, ...
Scientific reports 8 (1), 1-13, 2018
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
H Liu, SA Shiryaev, AV Chernov, Y Kim, I Shubayev, AG Remacle, ...
Journal of neuroinflammation 9 (1), 1-18, 2012
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