| Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold AE Aleshin, SA Shiryaev, AY Strongin, RC Liddington Protein science 16 (5), 795-806, 2007 | 207 | 2007 |
| Substrate cleavage analysis of furin and related proprotein convertases: a comparative study AG Remacle, SA Shiryaev, ES Oh, P Cieplak, A Srinivasan, G Wei, ... Journal of Biological Chemistry 283 (30), 20897-20906, 2008 | 129 | 2008 |
| Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism S D'Alessio, G Ferrari, K Cinnante, W Scheerer, AC Galloway, DF Roses, ... Journal of Biological Chemistry 283 (1), 87-99, 2008 | 120 | 2008 |
| Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer M Ouyang, H Huang, NC Shaner, AG Remacle, SA Shiryaev, AY Strongin, ... Cancer research 70 (6), 2204-2212, 2010 | 116 | 2010 |
| Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis SA Shiryaev, AY Savinov, P Cieplak, BI Ratnikov, K Motamedchaboki, ... PloS one 4 (3), e4952, 2009 | 111 | 2009 |
| Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth AG Remacle, VS Golubkov, SA Shiryaev, R Dahl, JL Stebbins, ... Cancer research 72 (9), 2339-2349, 2012 | 109 | 2012 |
| HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ... Assay and drug development technologies 5 (6), 737-750, 2007 | 108 | 2007 |
| Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens SA Shiryaev, AG Remacle, BI Ratnikov, NA Nelson, AY Savinov, G Wei, ... Journal of Biological Chemistry 282 (29), 20847-20853, 2007 | 106 | 2007 |
| Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase SA Shiryaev, BI Ratnikov, AV Chekanov, S Sikora, DV Rozanov, A Godzik, ... Biochemical Journal 393 (2), 503-511, 2006 | 104 | 2006 |
| Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis SA Shiryaev, P Mesci, A Pinto, I Fernandes, N Sheets, S Shresta, C Farhy, ... Scientific reports 7 (1), 1-9, 2017 | 99 | 2017 |
| NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus SA Shiryaev, AV Chernov, AE Aleshin, TN Shiryaeva, AY Strongin The Journal of general virology 90 (Pt 9), 2081, 2009 | 92 | 2009 |
| The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration Y Kim, AG Remacle, AV Chernov, H Liu, I Shubayev, C Lai, J Dolkas, ... PloS one 7 (3), e33664, 2012 | 88 | 2012 |
| Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses SA Shiryaev, IA Kozlov, BI Ratnikov, JW Smith, M Lebl, AY Strongin Biochemical Journal 401 (3), 743-752, 2007 | 79 | 2007 |
| Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists SA Shiryaev, C Farhy, A Pinto, CT Huang, N Simonetti, AE Ngono, ... Antiviral research 143, 218-229, 2017 | 77 | 2017 |
| Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry S Yang, M Xu, EM Lee, K Gorshkov, SA Shiryaev, S He, W Sun, ... Cell discovery 4 (1), 1-14, 2018 | 67 | 2018 |
| Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase S Sidique, SA Shiryaev, BI Ratnikov, A Herath, Y Su, AY Strongin, ... Bioorganic & medicinal chemistry letters 19 (19), 5773-5777, 2009 | 56 | 2009 |
| Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis SA Shiryaev, BI Ratnikov, AE Aleshin, IA Kozlov, NA Nelson, M Lebl, ... Journal of virology 81 (9), 4501-4509, 2007 | 50 | 2007 |
| Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis SA Shiryaev, AG Remacle, AY Savinov, AV Chernov, P Cieplak, ... Journal of Biological Chemistry 284 (44), 30615-30626, 2009 | 47 | 2009 |
| Blocking Zika virus vertical transmission P Mesci, A Macia, SM Moore, SA Shiryaev, A Pinto, CT Huang, L Tejwani, ... Scientific reports 8 (1), 1-13, 2018 | 46 | 2018 |
| Immunodominant fragments of myelin basic protein initiate T cell-dependent pain H Liu, SA Shiryaev, AV Chernov, Y Kim, I Shubayev, AG Remacle, ... Journal of neuroinflammation 9 (1), 1-18, 2012 | 46 | 2012 |
Alex StronginProfessor, SBMRIVerified email at sbpdiscovery.org
