Pär Matsson
Pär Matsson
Professor of Pharmacokinetics, Sahlgrenska Academy, University of Gothenburg
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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs
P Matsson, JM Pedersen, U Norinder, CAS Bergström, P Artursson
Pharmaceutical research 26, 1816-1831, 2009
Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver
X Chu, K Korzekwa, R Elsby, K Fenner, A Galetin, Y Lai, P Matsson, ...
Clinical Pharmacology & Therapeutics 94 (1), 126-141, 2013
Cell permeability beyond the rule of 5
P Matsson, BC Doak, B Over, J Kihlberg
Advanced drug delivery reviews 101, 42-61, 2016
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
G Ahlin, J Karlsson, JM Pedersen, L Gustavsson, R Larsson, P Matsson, ...
Journal of medicinal chemistry 51 (19), 5932-5942, 2008
How big is too big for cell permeability?
P Matsson, J Kihlberg
Journal of Medicinal Chemistry 60 (5), 1662-1664, 2017
Impact of dynamically exposed polarity on permeability and solubility of chameleonic drugs beyond the rule of 5
M Rossi Sebastiano, BC Doak, M Backlund, V Poongavanam, B Over, ...
Journal of Medicinal Chemistry 61 (9), 4189-4202, 2018
Profiling of a prescription drug library for potential renal drug–drug interactions mediated by the organic cation transporter 2
Y Kido, P Matsson, KM Giacomini
Journal of medicinal chemistry 54 (13), 4548-4558, 2011
Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11)
JM Pedersen, P Matsson, CAS Bergström, J Hoogstraate, A Norén, ...
toxicological sciences 136 (2), 328-343, 2013
Structural and conformational determinants of macrocycle cell permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature Chemical Biology 12 (12), 1065-1074, 2016
Exploring the role of different drug transport routes in permeability screening
P Matsson, CAS Bergström, N Nagahara, S Tavelin, U Norinder, ...
Journal of medicinal chemistry 48 (2), 604-613, 2005
Rapid measurement of intracellular unbound drug concentrations
A Mateus, P Matsson, P Artursson
Molecular pharmaceutics 10 (6), 2467-2478, 2013
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)
JM Pedersen, P Matsson, CAS Bergström, U Norinder, J Hoogstraate, ...
Journal of medicinal chemistry 51 (11), 3275-3287, 2008
A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein (ABCG2)
P Matsson, G Englund, G Ahlin, CAS Bergström, U Norinder, P Artursson
Journal of Pharmacology and Experimental Therapeutics 323 (1), 19-30, 2007
Comparison of human solute carriers
A Schlessinger, P Matsson, JE Shima, U Pieper, SW Yee, L Kelly, ...
Protein Science 19 (3), 412-428, 2010
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
Y Guo, X Chu, NJ Parrott, KLR Brouwer, V Hsu, S Nagar, P Matsson, ...
Clinical Pharmacology & Therapeutics 104 (5), 865-889, 2018
Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties
B Over, P McCarren, P Artursson, M Foley, F Giordanetto, G Grönberg, ...
Journal of medicinal chemistry 57 (6), 2746-2754, 2014
Prediction of intracellular exposure bridges the gap between target-and cell-based drug discovery
A Mateus, LJ Gordon, GJ Wayne, H Almqvist, H Axelsson, ...
Proceedings of the National Academy of Sciences 114 (30), E6231-E6239, 2017
Intracellular drug bioavailability: a new predictor of system dependent drug disposition
A Mateus, A Treyer, C Wegler, M Karlgren, P Matsson, P Artursson
Scientific reports 7 (1), 43047, 2017
The proteome of filter-grown Caco-2 cells with a focus on proteins involved in drug disposition
M Ölander, JR Wiśniewski, P Matsson, P Lundquist, P Artursson
Journal of pharmaceutical sciences 105 (2), 817-827, 2016
Complete knockout of endogenous Mdr1 (Abcb1) in MDCK cells by CRISPR-Cas9
I Simoff, M Karlgren, M Backlund, AC Lindström, FZ Gaugaz, P Matsson, ...
Journal of pharmaceutical sciences 105 (2), 1017-1021, 2016
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