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Emmanuel Margolin
Emmanuel Margolin
Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
Verifierad e-postadress på uct.ac.za
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Production of complex viral glycoproteins in plants as vaccine immunogens
E Margolin, R Chapman, AL Williamson, EP Rybicki, AE Meyers
Plant biotechnology journal 16 (9), 1531-1545, 2018
792018
Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa
E Margolin, WA Burgers, ED Sturrock, M Mendelson, R Chapman, ...
Nature Reviews Microbiology 18 (12), 690-704, 2020
562020
Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants
E Margolin, YJ Oh, M Verbeek, J Naude, D Ponndorf, YA Meshcheriakova, ...
Plant Biotechnology Journal 18 (10), 2109-2117, 2020
562020
N-glycosylation of the SARS-CoV-2 receptor binding domain is important for functional expression in plants
YJ Shin, J König-Beihammer, U Vavra, J Schwestka, NF Kienzl, ...
Frontiers in Plant Science 12, 689104, 2021
462021
Engineering the plant secretory pathway for the production of next-generation pharmaceuticals
EA Margolin, R Strasser, R Chapman, AL Williamson, EP Rybicki, ...
Trends in biotechnology 38 (9), 1034-1044, 2020
462020
Production and immunogenicity of soluble plant-produced HIV-1 subtype C envelope gp140 immunogens
E Margolin, R Chapman, AE Meyers, MT Van Diepen, P Ximba, ...
Frontiers in plant science 10, 1378, 2019
402019
Prime-boost immunizations with DNA, modified vaccinia virus Ankara, and protein-based vaccines elicit robust HIV-1 tier 2 neutralizing antibodies against the CAP256 …
MT van Diepen, R Chapman, N Douglass, S Galant, PL Moore, ...
Journal of virology 93 (8), 10.1128/jvi. 02155-18, 2019
352019
A roadmap for the molecular farming of viral glycoprotein vaccines: engineering glycosylation and glycosylation-directed folding
E Margolin, M Crispin, A Meyers, R Chapman, EP Rybicki
Frontiers in Plant Science 11, 609207, 2020
252020
The adjuvant AlhydroGel elicits higher antibody titres than AddaVax when combined with HIV-1 subtype C gp140 from CAP256
MT van Diepen, R Chapman, PL Moore, E Margolin, T Hermanus, ...
PLoS One 13 (12), e0208310, 2018
202018
Immunogenicity of HIV-1 vaccines expressing chimeric envelope glycoproteins on the surface of Pr55 Gag virus-like particles
R Chapman, M van Diepen, S Galant, E Kruse, E Margolin, P Ximba, ...
Vaccines 8 (1), 54, 2020
142020
Site-specific glycosylation of recombinant viral glycoproteins produced in Nicotiana benthamiana
E Margolin, JD Allen, M Verbeek, M Van Diepen, P Ximba, R Chapman, ...
Frontiers in Plant Science 12, 709344, 2021
132021
A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters
E Margolin, G Schäfer, JD Allen, S Gers, J Woodward, AD Sutherland, ...
Frontiers in Plant Science 14, 1146234, 2023
122023
Calreticulin co-expression supports high level production of a recombinant SARS-CoV-2 spike mimetic in Nicotiana benthamiana
E Margolin, M Verbeek, A Meyers, R Chapman, AL Williamson, ...
BioRxiv, 2020.06. 14.150458, 2020
102020
Investigating constraints along the plant secretory pathway to improve production of a SARS-CoV-2 spike vaccine candidate
E Margolin, M Verbeek, W de Moor, R Chapman, A Meyers, G Schäfer, ...
Frontiers in Plant Science 12, 798822, 2022
92022
Assessment of an LSDV-vectored vaccine for heterologous prime-boost immunizations against HIV
R Chapman, M van Diepen, N Douglass, S Galant, M Jaffer, E Margolin, ...
Vaccines 9 (11), 1281, 2021
62021
Development of a synthetic nanoparticle vaccine presenting the HIV-1 envelope glycoprotein
P Ximba, R Chapman, A Meyers, E Margolin, MT van Diepen, AF Sander, ...
Nanotechnology 33 (48), 485102, 2022
52022
Characterization and Immunogenicity of HIV Envelope gp140 Zera® Tagged Antigens
P Ximba, R Chapman, AE Meyers, E Margolin, MT Van Diepen, ...
Frontiers in Bioengineering and Biotechnology 8, 321, 2020
52020
Augmenting glycosylation‐directed folding pathways enhances the fidelity of HIV Env immunogen production in plants
E Margolin, JD Allen, M Verbeek, R Chapman, A Meyers, M van Diepen, ...
Biotechnology and Bioengineering 119 (10), 2919-2937, 2022
42022
Co-expression of human chaperone proteins in plants for increased expression of heterologous polypeptides
AE Meyers, EP Rybicki, EA Margolin
US Patent 11,555,196, 2023
22023
Modifications to the HIV-1 SAAVI MVA-C vaccine improve in vitro expression and in vivo immunogenicity
N Douglass, MT van Diepen, R Chapman, S Galant, E Margolin, P Ximba, ...
Vaccine 39 (3), 463-468, 2021
22021
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