| PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 C Kondapalli, A Kazlauskaite, N Zhang, HI Woodroof, DG Campbell, ... Open biology 2 (5), 120080, 2012 | 421 | 2012 |
| Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases M Zhuang, MF Calabrese, J Liu, MB Waddell, A Nourse, M Hammel, ... Molecular cell 36 (1), 39-50, 2009 | 230 | 2009 |
| Ubiquitin signalling in DNA replication and repair HD Ulrich, H Walden Nature reviews Molecular cell biology 11 (7), 479, 2010 | 229 | 2010 |
| Autoregulation of Parkin activity through its ubiquitin‐like domain VK Chaugule, L Burchell, KR Barber, A Sidhu, SJ Leslie, GS Shaw, ... The EMBO journal 30 (14), 2853-2867, 2011 | 220 | 2011 |
| The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor Jr, ... Molecular cell 12 (6), 1427-1437, 2003 | 205 | 2003 |
| Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 H Walden, MS Podgorski, BA Schulman Nature 422 (6929), 330, 2003 | 201 | 2003 |
| The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder H Walden, AJ Deans Annual review of biophysics 43, 257-278, 2014 | 155 | 2014 |
| Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, ... Nature immunology 6 (4), 382, 2005 | 148 | 2005 |
| Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability KE Marshall, KL Morris, D Charlton, N O’Reilly, L Lewis, H Walden, ... Biochemistry 50 (12), 2061-2071, 2011 | 146 | 2011 |
| RBR E3 ubiquitin ligases: new structures, new insights, new questions DE Spratt, H Walden, GS Shaw Biochemical journal 458 (3), 421-437, 2014 | 140 | 2014 |
| Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase H Walden, GS Bell, RJM Russell, B Siebers, R Hensel, GL Taylor Journal of molecular biology 306 (4), 745-757, 2001 | 139 | 2001 |
| Ubiquitin-like protein activation DT Huang, H Walden, D Duda, BA Schulman Oncogene 23 (11), 1958, 2004 | 92 | 2004 |
| Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ... The EMBO journal 34 (20), 2506-2521, 2015 | 89 | 2015 |
| Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK1‐dependent phosphorylation and activation A Kazlauskaite, RJ Martínez‐Torres, S Wilkie, A Kumar, J Peltier, ... EMBO reports 16 (8), 939-954, 2015 | 88 | 2015 |
| A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease DE Spratt, RJ Martinez-Torres, YJ Noh, P Mercier, N Manczyk, KR Barber, ... Nature communications 4, 1983, 2013 | 86 | 2013 |
| The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus A Theodossis, H Walden, EJ Westwick, H Connaris, HJ Lamble, ... Journal of Biological Chemistry 279 (42), 43886-43892, 2004 | 75 | 2004 |
| The structure of the catalytic subunit FANCL of the Fanconi anemia core complex AR Cole, LPC Lewis, H Walden Nature structural & molecular biology 17 (3), 294, 2010 | 71 | 2010 |
| Selenium incorporation using recombinant techniques H Walden Acta Crystallographica Section D: Biological Crystallography 66 (4), 352-357, 2010 | 64 | 2010 |
| Types of ubiquitin ligases FE Morreale, H Walden Cell 165 (1), 248-248. e1, 2016 | 61 | 2016 |
| Regulation of Parkin E3 ubiquitin ligase activity H Walden, RJ Martinez-Torres Cellular and Molecular Life Sciences 69 (18), 3053-3067, 2012 | 57 | 2012 |