Helen Walden
Helen Walden
Verified email at glasgow.ac.uk
TitleCited byYear
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
C Kondapalli, A Kazlauskaite, N Zhang, HI Woodroof, DG Campbell, ...
Open biology 2 (5), 120080, 2012
4472012
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases
M Zhuang, MF Calabrese, J Liu, MB Waddell, A Nourse, M Hammel, ...
Molecular cell 36 (1), 39-50, 2009
2462009
Ubiquitin signalling in DNA replication and repair
HD Ulrich, H Walden
Nature reviews Molecular cell biology 11 (7), 479, 2010
2412010
Autoregulation of Parkin activity through its ubiquitin‐like domain
VK Chaugule, L Burchell, KR Barber, A Sidhu, SJ Leslie, GS Shaw, ...
The EMBO journal 30 (14), 2853-2867, 2011
2282011
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor Jr, ...
Molecular cell 12 (6), 1427-1437, 2003
2122003
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
H Walden, MS Podgorski, BA Schulman
Nature 422 (6929), 330, 2003
2042003
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder
H Walden, AJ Deans
Annual review of biophysics 43, 257-278, 2014
1722014
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability
KE Marshall, KL Morris, D Charlton, N O’Reilly, L Lewis, H Walden, ...
Biochemistry 50 (12), 2061-2071, 2011
1542011
RBR E3 ubiquitin ligases: new structures, new insights, new questions
DE Spratt, H Walden, GS Shaw
Biochemical journal 458 (3), 421-437, 2014
1532014
Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, ...
Nature immunology 6 (4), 382, 2005
1522005
Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase
H Walden, GS Bell, RJM Russell, B Siebers, R Hensel, GL Taylor
Journal of molecular biology 306 (4), 745-757, 2001
1422001
Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK1‐dependent phosphorylation and activation
A Kazlauskaite, RJ Martínez‐Torres, S Wilkie, A Kumar, J Peltier, ...
EMBO reports 16 (8), 939-954, 2015
952015
Ubiquitin-like protein activation
DT Huang, H Walden, D Duda, BA Schulman
Oncogene 23 (11), 1958, 2004
942004
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis
A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ...
The EMBO journal 34 (20), 2506-2521, 2015
922015
A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
DE Spratt, RJ Martinez-Torres, YJ Noh, P Mercier, N Manczyk, KR Barber, ...
Nature communications 4, 1983, 2013
882013
Types of ubiquitin ligases
FE Morreale, H Walden
Cell 165 (1), 248-248. e1, 2016
762016
The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
AR Cole, LPC Lewis, H Walden
Nature structural & molecular biology 17 (3), 294, 2010
752010
The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus
A Theodossis, H Walden, EJ Westwick, H Connaris, HJ Lamble, ...
Journal of Biological Chemistry 279 (42), 43886-43892, 2004
752004
Selenium incorporation using recombinant techniques
H Walden
Acta Crystallographica Section D: Biological Crystallography 66 (4), 352-357, 2010
712010
Regulation of Parkin E3 ubiquitin ligase activity
H Walden, RJ Martinez-Torres
Cellular and Molecular Life Sciences 69 (18), 3053-3067, 2012
592012
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Articles 1–20