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Berthold Wroblowski
Berthold Wroblowski
Senior scientist,Janssen, Pharmaceutical Companies of Johnson and Johnson
Verifierad e-postadress på its.jnj.com
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Interaction of the p85 subunit of PI 3‐kinase and its N‐terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.
G Panayotou, B Bax, I Gout, M Federwisch, B Wroblowski, R Dhand, ...
The EMBO journal 11 (12), 4261-4272, 1992
1511992
Structure‐function analysis of human interleukin‐6: Evidence for the involvement of the carboxy‐terminus in function
A Krüttgen, S Rose-John, C Möller, B Wroblowski, A Wollmer, J Müllberg, ...
FEBS letters 262 (2), 323-326, 1990
931990
Molecular mechanisms of pressure induced conformational changes in BPTI
B Wroblowski, JF Díaz, K Heremans, Y Engelborghs
Proteins: Structure, Function, and Bioinformatics 25 (4), 446-455, 1996
911996
5-Substituted pyrimidines with a 1, 5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral …
T Ostrowski, B Wroblowski, R Busson, J Rozenski, E De Clercq, ...
Journal of medicinal chemistry 41 (22), 4343-4353, 1998
791998
Calculation of pathways for the conformational transition between the GTP‐ and GDP‐bound states of the Ha‐ras‐p21 protein: Calculations with explicit solvent …
J Fernando Díaz, B Wroblowski, J Schlitter, Y Engelborghs
Proteins: Structure, Function, and Bioinformatics 28 (3), 434-451, 1997
791997
Extending kinome coverage by analysis of kinase inhibitor broad profiling data
E Jacoby, G Tresadern, S Bembenek, B Wroblowski, C Buyck, JM Neefs, ...
Drug Discovery Today 20 (6), 652-658, 2015
542015
Small molecule binding to Alzheimer risk factor CD33 promotes Aβ phagocytosis
LA Miles, SJ Hermans, GAN Crespi, JH Gooi, L Doughty, TL Nero, ...
Iscience 19, 110-118, 2019
532019
Molecular dynamics simulation of the solution structures of Ha-ras-p21 GDP and GTP complexes: flexibility, possible hinges, and levers of the conformational transition
JF Diaz, B Wroblowski, Y Engelborghs
Biochemistry 34 (37), 12038-12047, 1995
471995
Modelling pathways of alpha-chymotrypsin activation and deactivation.
B Wroblowski, JF Diaz, J Schlitter, Y Engelborghs
Protein engineering 10 (10), 1163-1174, 1997
451997
Pyrazolyl quinoxaline kinase inhibitors
G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ...
US Patent 8,895,601, 2014
352014
Oligonucleotide Analogues with 4‐Hydroxy‐N‐Acetylprolinol as Sugar Substitute
G Ceulemans, A Van Aerschot, B Wroblowski, J Rozenski, C Hendrix, ...
Chemistry–A European Journal 3 (12), 1997-2010, 1997
301997
Oligonucleotides Composed of 2‘-Deoxy-1‘,5‘-anhydro-d-mannitol Nucleosides with a Purine Base Moiety
N Hossain, B Wroblowski, A Van Aerschot, J Rozenski, A De Bruyn, ...
The Journal of Organic Chemistry 63 (5), 1574-1582, 1998
281998
Some 6-aza-5-substituted-2′-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase
I Basnak, M Sun, TA Hamor, F Focher, A Verri, S Spadari, B Wroblowski, ...
Nucleosides & nucleotides 17 (1-3), 187-206, 1998
281998
Pyrazolyl quinoxaline kinase inhibitors
G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ...
US Patent 9,464,071, 2016
252016
Molecular‐Dynamics Studies of Single‐Stranded Hexitol, Altritol, Mannitol, and Ribose Nucleic Acids (HNA, MNA, ANA, and RNA, Resp.) and of the Stability of HNA⋅ RNA, ANA⋅ RNA …
M Froeyen, B Wroblowski, R Esnouf, H De Winter, B Allart, E Lescrinier, ...
Helvetica Chimica Acta 83 (9), 2153-2182, 2000
212000
Pyrazolyl quinoxaline kinase inhibitors
G Saxty, CW Murray, V Berdini, GE Besong, CCF Hamlett, CN Johnson, ...
US Patent 9,850,228, 2017
202017
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor
B Wroblowski, MJ Wigglesworth, PG Szekeres, GD Smith, SS Rahman, ...
Journal of medicinal chemistry 52 (3), 818-825, 2009
172009
Prediction of protein kinase–ligand interactions through 2.5 D kinochemometrics
N Bosc, B Wroblowski, C Meyer, P Bonnet
Journal of chemical information and modeling 57 (1), 93-101, 2017
162017
A proteometric analysis of human kinome: insight into discriminant conformation-dependent residues
N Bosc, B Wroblowski, S Aci-Sèche, C Meyer, P Bonnet
ACS Chemical Biology 10 (12), 2827-2840, 2015
152015
Pyrazolyl quinoxaline kinase inhibitors
G Saxty, CW Murray, V Berdini, GE Besong, SJ Woodhead, M Reader, ...
US Patent 10,519,137, 2019
142019
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