| Structural basis for the highly selective inhibition of MMP-13 CK Engel, B Pirard, S Schimanski, R Kirsch, J Habermann, O Klingler, ... Chemistry & biology 12 (2), 181-189, 2005 | 256 | 2005 |
| Molecular basis for Kv1. 5 channel block: conservation of drug binding sites among voltage-gated K+ channels N Decher, B Pirard, F Bundis, S Peukert, KH Baringhaus, AE Busch, ... Journal of Biological Chemistry 279 (1), 394-400, 2004 | 159 | 2004 |
| Classification of kinase inhibitors using BCUT descriptors B Pirard, SD Pickett Journal of Chemical Information and Computer Sciences 40 (6), 1431-1440, 2000 | 126 | 2000 |
| Computational approaches towards the rational design of drug-like compound libraries H Matter, KH Barighaus, T Naumann, T Klabunde, B Pirard Combinatorial chemistry & high throughput screening 4 (6), 453-475, 2001 | 122 | 2001 |
| Insight into the structural determinants for selective inhibition of matrix metalloproteinases B Pirard Drug discovery today 12 (15-16), 640-646, 2007 | 121 | 2007 |
| Binding site of a novel Kv1. 5 blocker: a “foot in the door” against atrial fibrillation N Decher, P Kumar, T Gonzalez, B Pirard, MC Sanguinetti Molecular pharmacology 70 (4), 1204-1211, 2006 | 117 | 2006 |
| Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1. 5 S Peukert, J Brendel, B Pirard, A Brüggemann, P Below, HW Kleemann, ... Journal of medicinal chemistry 46 (4), 486-498, 2003 | 108 | 2003 |
| A structure-based design approach to the development of novel, reversible AChE inhibitors C Doucet-Personeni, PD Bentley, RJ Fletcher, A Kinkaid, G Kryger, ... Journal of Medicinal Chemistry 44 (20), 3203-3215, 2001 | 78 | 2001 |
| Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1. 5 channel S Peukert, J Brendel, B Pirard, C Strübing, HW Kleemann, T Böhme, ... Bioorganic & medicinal chemistry letters 14 (11), 2823-2827, 2004 | 69 | 2004 |
| Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis B Pirard, H Matter Journal of medicinal chemistry 49 (1), 51-69, 2006 | 64 | 2006 |
| The discovery of Kv1. 5 blockers as a case study for the application of virtual screening approaches B Pirard, J Brendel, S Peukert Journal of chemical information and modeling 45 (2), 477-485, 2005 | 53 | 2005 |
| A database study of intermolecular NH⋯ O hydrogen bonds for carboxylates, sulfonates and monohydrogen phosphonates B Pirard, G Baudoux, F Durant Acta Crystallographica Section B: Structural Science 51 (1), 103-107, 1995 | 53 | 1995 |
| N-((6-amino-pyridin-3-yl) methyl)-heteroaryl-carboxamides T Brandl, S Flohr, S Kopec, J Lachal, C Markert, K Namoto, P Nganga, ... US Patent 9,290,485, 2016 | 41 | 2016 |
| Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis B Pirard Journal of computer-aided molecular design 17 (11), 785-796, 2003 | 30 | 2003 |
| New pyrazolo [1, 5a] pyrimidines as orally active inhibitors of Lck N Gommermann, P Buehlmayer, A Von Matt, W Breitenstein, K Masuya, ... Bioorganic & medicinal chemistry letters 20 (12), 3628-3631, 2010 | 29 | 2010 |
| Computational methods for the identification and optimisation of high quality leads B Pirard Combinatorial Chemistry & High Throughput Screening 7 (4), 271-280, 2004 | 26 | 2004 |
| 5-Membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors S Flohr, C Markert, K Namoto, B Pirard US Patent App. 14/371,457, 2014 | 25 | 2014 |
| The quest for novel chemical matter and the contribution of computer-aided de novo design B Pirard Expert Opinion on Drug Discovery 6 (3), 225-231, 2011 | 22 | 2011 |
| 3-Benzo [b] furyl-and 3-benzo [b] thienylaminobutyric acids as GABAB ligands. Synthesis and structure-activity relationship studies M Ansar, S Al Akoum Ebriki, R Mouhoub, P Berthelot, C Vaccher, ... European journal of medicinal chemistry 31 (6), 449-460, 1996 | 17 | 1996 |
| CAVIAR: a method for automatic cavity detection, description and decomposition into subcavities JR Marchand, B Pirard, P Ertl, F Sirockin Journal of Computer-Aided Molecular Design 35 (6), 737-750, 2021 | 13 | 2021 |
