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Thorsten Lehr
Thorsten Lehr
Verifierad e-postadress på mx.uni-saarland.de
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The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY …
PA Reilly, T Lehr, S Haertter, SJ Connolly, S Yusuf, JW Eikelboom, ...
Journal of the American College of Cardiology 63 (4), 321-328, 2014
9642014
Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study
P Bogomolov, A Alexandrov, N Voronkova, M Macievich, K Kokina, ...
Journal of hepatology 65 (3), 490-498, 2016
4312016
Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trial
KH Liesenfeld, T Lehr, C Dansirikul, PA Reilly, SJ Connolly, ...
Journal of Thrombosis and Haemostasis 9 (11), 2168-2175, 2011
3832011
Genetic determinants of dabigatran plasma levels and their relation to bleeding
G Paré, N Eriksson, T Lehr, S Connolly, J Eikelboom, MD Ezekowitz, ...
Circulation 127 (13), 1404-1412, 2013
3342013
Effective elimination of dabigatran by haemodialysis
D Khadzhynov, F Wagner, S Formella, E Wiegert, V Moschetti, T Slowinski, ...
Thrombosis and haemostasis 109 (04), 596-605, 2013
2502013
A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: THE Randomized, phase II study to evaluate the safety and pharmacokinetics of oral …
F Van de Werf, M Brueckmann, SJ Connolly, J Friedman, CB Granger, ...
American heart journal 163 (6), 931-937. e1, 2012
2372012
First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B
A Blank, C Markert, N Hohmann, A Carls, G Mikus, T Lehr, A Alexandrov, ...
Journal of hepatology 65 (3), 483-489, 2016
2212016
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
JJ Swen, CH van der Wouden, LEN Manson, H Abdullah-Koolmees, ...
The Lancet 401 (10374), 347-356, 2023
1642023
PBPK models for CYP3A4 and P‐gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, and digoxin
N Hanke, S Frechen, D Moj, H Britz, T Eissing, T Wendl, T Lehr
CPT: pharmacometrics & systems pharmacology 7 (10), 647-659, 2018
1252018
Dabigatran etexilate in atrial fibrillation patients with severe renal impairment: dose identification using pharmacokinetic modeling and simulation
T Lehr, S Haertter, KH Liesenfeld, A Staab, A Clemens, PA Reilly, ...
The Journal of Clinical Pharmacology 52 (9), 1373-1378, 2012
1122012
Investigators RL. The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation …
PA Reilly, T Lehr, S Haertter, SJ Connolly, S Yusuf, JW Eikelboom, ...
J Am Coll Cardiol 63 (4), 321-8, 2014
832014
Vacuolar-ATPase inhibition blocks iron metabolism to mediate therapeutic effects in breast cancer
LS Schneider, K Von Schwarzenberg, T Lehr, M Ulrich, ...
Cancer research 75 (14), 2863-2874, 2015
802015
Targeting cyclin dependent kinase 5 in hepatocellular carcinoma–A novel therapeutic approach
SM Ehrlich, J Liebl, MA Ardelt, T Lehr, EN De Toni, D Mayr, L Brandl, ...
Journal of hepatology 63 (1), 102-113, 2015
802015
Open systems pharmacology community—an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences
J Lippert, R Burghaus, A Edginton, S Frechen, M Karlsson, A Kovar, ...
CPT: pharmacometrics & systems pharmacology 8 (12), 878, 2019
732019
Population nutrikinetics of green tea extract
C Scholl, A Lepper, T Lehr, N Hanke, KL Schneider, J Brockmöller, ...
PLoS One 13 (2), e0193074, 2018
722018
Data digitizing: accurate and precise data extraction for quantitative systems pharmacology and physiologically‐based pharmacokinetic modeling
JG Wojtyniak, H Britz, D Selzer, M Schwab, T Lehr
CPT: Pharmacometrics & Systems Pharmacology 9 (6), 322-331, 2020
622020
How to disentangle psychobiological stress reactivity and recovery: A comparison of model-based and non-compartmental analyses of cortisol concentrations
R Miller, JG Wojtyniak, LJ Weckesser, NC Alexander, V Engert, T Lehr
Psychoneuroendocrinology 90, 194-210, 2018
592018
Biosimulation in clinical drug development
T Lehr, A Staab, HG Schäfer
Biosimulation in drug development, 447-483, 2008
57*2008
Pharmacometric characterization of dabigatran hemodialysis
KH Liesenfeld, A Staab, S Härtter, S Formella, A Clemens, T Lehr
Clinical pharmacokinetics 52, 453-462, 2013
562013
Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: a pharmacokinetic justification
A Clemens, S Haertter, J Friedman, M Brueckmann, J Stangier, J van Ryn, ...
Current medical research and opinion 28 (2), 195-201, 2012
522012
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