Ganesh M Shankar
Ganesh M Shankar
Verifierad e-postadress på partners.org
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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ...
Nature medicine 14 (8), 837-842, 2008
34532008
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
JP Cleary, DM Walsh, JJ Hofmeister, GM Shankar, MA Kuskowski, ...
Nature neuroscience 8 (1), 79-84, 2005
19082005
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
GM Shankar, BL Bloodgood, M Townsend, DM Walsh, DJ Selkoe, ...
Journal of Neuroscience 27 (11), 2866-2875, 2007
16222007
Soluble oligomers of amyloid β protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
S Li, S Hong, NE Shepardson, DM Walsh, GM Shankar, D Selkoe
Neuron 62 (6), 788-801, 2009
8422009
Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers
M Townsend, GM Shankar, T Mehta, DM Walsh, DJ Selkoe
The Journal of physiology 572 (2), 477-492, 2006
6802006
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
I Klyubin, DM Walsh, CA Lemere, WK Cullen, GM Shankar, V Betts, ...
Nature medicine 11 (5), 556-561, 2005
6052005
Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases
GB Irvine, OM El-Agnaf, GM Shankar, DM Walsh
Molecular medicine 14 (7), 451-464, 2008
5302008
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
S Li, M Jin, T Koeglsperger, NE Shepardson, GM Shankar, DJ Selkoe
Journal of Neuroscience 31 (18), 6627-6638, 2011
5272011
Alzheimer's disease: synaptic dysfunction and Aβ
GM Shankar, DM Walsh
Molecular neurodegeneration 4 (1), 48, 2009
4592009
Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system
Y Oda
Pathology international 49 (11), 921-937, 1999
4001999
Certain inhibitors of synthetic amyloid β-peptide (Aβ) fibrillogenesis block oligomerization of natural Aβ and thereby rescue long-term potentiation
DM Walsh, M Townsend, MB Podlisny, GM Shankar, JV Fadeeva, ...
Journal of Neuroscience 25 (10), 2455-2462, 2005
3572005
The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention
DM Walsh, I Klyubin, GM Shankar, M Townsend, JV Fadeeva, V Betts, ...
Biochemical Society Transactions 33 (5), 1087-1090, 2005
2782005
The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
JM Mc Donald, GM Savva, C Brayne, AT Welzel, G Forster, GM Shankar, ...
Brain 133 (5), 1328-1341, 2010
2642010
Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies
NE Shepardson, GM Shankar, DJ Selkoe
Archives of neurology 68 (10), 1239-1244, 2011
2062011
A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease
W Xia, T Yang, G Shankar, IM Smith, Y Shen, DM Walsh, DJ Selkoe
Archives of neurology 66 (2), 190-199, 2009
2062009
Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations
NE Shepardson, GM Shankar, DJ Selkoe
Archives of neurology 68 (11), 1385-1392, 2011
1732011
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy
W Farris, SG Schütz, JR Cirrito, GM Shankar, X Sun, A George, ...
The American journal of pathology 171 (1), 241-251, 2007
1662007
Discovery and validation of blood biomarkers for suicidality
H Le-Niculescu, DF Levey, M Ayalew, L Palmer, LM Gavrin, N Jain, ...
Molecular psychiatry 18 (12), 1249-1264, 2013
1612013
Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy
PK Brastianos, GM Shankar, CM Gill, A Taylor-Weiner, N Nayyar, ...
JNCI: Journal of the National Cancer Institute 108 (2), 2016
1312016
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life
GM Shankar, MA Leissring, A Adame, X Sun, E Spooner, E Masliah, ...
Neurobiology of disease 36 (2), 293-302, 2009
1272009
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