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Lihe Chen
Lihe Chen
Staff Scientist at the National Institutes of Health (NIH)
Verifierad e-postadress på nih.gov
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Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq
L Chen, JW Lee, CL Chou, AV Nair, MA Battistone, TG Păunescu, ...
Proceedings of the National Academy of Sciences 114 (46), E9989-E9998, 2017
2292017
A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse
L Chen, CL Chou, MA Knepper
Journal of the American Society of Nephrology 32 (4), 897-912, 2021
1322021
Representation and relative abundance of cell-type selective markers in whole-kidney RNA-Seq data
JZ Clark, L Chen, CL Chou, HJ Jung, JW Lee, MA Knepper
Kidney international 95 (4), 787-796, 2019
1102019
Renal-tubule epithelial cell nomenclature for single-cell RNA-sequencing studies
L Chen, JZ Clark, JW Nelson, B Kaissling, DH Ellison, MA Knepper
Journal of the American Society of Nephrology 30 (8), 1358-1364, 2019
932019
Aqp2-expressing cells give rise to renal intercalated cells
H Wu, L Chen, Q Zhou, X Zhang, S Berger, J Bi, DE Lewis, Y Xia, ...
Journal of the American Society of Nephrology 24 (2), 243-252, 2013
792013
Targeted single-cell RNA-seq identifies minority cell types of kidney distal nephron
L Chen, CL Chou, MA Knepper
Journal of the American Society of Nephrology 32 (4), 886-896, 2021
752021
Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2
H Wu, L Chen, X Zhang, Q Zhou, JM Li, S Berger, Z Borok, B Zhou, Z Xiao, ...
PloS one 8 (1), e53342, 2013
612013
Does SARS-CoV-2 infect the kidney?
S Khan, L Chen, CR Yang, V Raghuram, SJ Khundmiri, MA Knepper
Journal of the American Society of Nephrology 31 (12), 2746-2748, 2020
562020
Transcriptomes of major proximal tubule cell culture models
SJ Khundmiri, L Chen, ED Lederer, CR Yang, MA Knepper
Journal of the American Society of Nephrology 32 (1), 86-97, 2021
392021
Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4
J Berrout, M Mamenko, OL Zaika, L Chen, W Zang, O Pochynyuk, ...
PloS one 9 (4), e95149, 2014
392014
Loss of histone H3 K79 methyltransferase Dot1l facilitates kidney fibrosis by upregulating endothelin 1 through histone deacetylase 2
L Zhang, L Chen, C Gao, E Chen, AR Lightle, L Foulke, B Zhao, ...
Journal of the American Society of Nephrology 31 (2), 337-349, 2020
372020
RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus
CC Sung, L Chen, K Limbutara, HJ Jung, GG Gilmer, CR Yang, SH Lin, ...
Kidney international 96 (2), 363-377, 2019
302019
Af17 deficiency increases sodium excretion and decreases blood pressure
L Chen, H Wu, M Pochynyuk, MR Reisenauer, Z Zhang, L Huang, ...
Journal of the American Society of Nephrology 22 (6), 1076-1086, 2011
292011
“SLC-omics” of the kidney: solute transporters along the nephron
S Lewis, L Chen, V Raghuram, SJ Khundmiri, CL Chou, CR Yang, ...
American Journal of Physiology-Cell Physiology 321 (3), C507-C518, 2021
242021
An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene
W Zhang, Z Yu, H Wu, L Chen, Q Kong, BC Kone
American Journal of Physiology-Renal Physiology 304 (4), F367-F375, 2013
242013
Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats
Q Zhou, K Liu, H Wu, L Chen, V Pouranan, M Yuan, Z Xiao, W Peng, ...
Public Library of Science 7 (10), e47360, 2012
222012
Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice
Z Xiao, L Chen, Q Zhou, W Zhang
Experimental cell research 344 (2), 167-175, 2016
212016
AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells
H Wu, L Chen, Q Zhou, W Zhang
PLoS One 6 (11), e27429, 2011
192011
Urine AQP5 is a potential novel biomarker of diabetic nephropathy
Y Lu, L Chen, B Zhao, Z Xiao, T Meng, Q Zhou, W Zhang
Journal of Diabetes and its Complications 30 (5), 819-825, 2016
142016
Regulation of αENaC transcription
L Chen, X Zhang, W Zhang
Vitamins & Hormones 98, 101-135, 2015
142015
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Artiklar 1–20