Tamas Hegedus
Tamas Hegedus
Semmelweis University
Verifierad e-postadress på hegelab.org - Startsida
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Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
AWR Serohijos, T Hegedűs, AA Aleksandrov, L He, L Cui, NV Dokholyan, ...
Proceedings of the National Academy of Sciences 105 (9), 3256-3261, 2008
4022008
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter
C Özvegy-Laczka, T Hegedűs, G Várady, O Ujhelly, JD Schuetz, A Varadi, ...
Molecular pharmacology 65 (6), 1485-1495, 2004
3762004
Mechanism-based corrector combination restores ΔF508-CFTR folding and function
T Okiyoneda, G Veit, JF Dekkers, M Bagdany, N Soya, H Xu, A Roldan, ...
Nature chemical biology 9 (7), 444, 2013
3132013
Membrane topology and glycosylation of the human multidrug resistance-associated protein
É Bakos, T Hegedüs, Z Holló, E Welker, GE Tusnády, GJR Zaman, ...
Journal of Biological Chemistry 271 (21), 12322-12326, 1996
2611996
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression
G Veit, RG Avramescu, D Perdomo, PW Phuan, M Bagdany, PM Apaja, ...
Science translational medicine 6 (246), 246ra97-246ra97, 2014
2462014
Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
T Hegedűs, L Őrfi, A Seprődi, A Váradi, B Sarkadi, G Kéri
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002
2322002
Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells
Z Holló, L Homolya, T Hegedüs, B Sarkadi
FEBS letters 383 (1-2), 99-104, 1996
2201996
Domain interdependence in the biosynthetic assembly of CFTR
L Cui, L Aleksandrov, XB Chang, YX Hou, L He, T Hegedus, M Gentzsch, ...
Journal of molecular biology 365 (4), 981-994, 2007
2112007
HAEdb: A novel interactive, locus‐specific mutation database for the C1 inhibitor gene
L Kalmár, T Hegedüs, H Farkas, M Nagy, A Tordai
Human mutation 25 (1), 1-5, 2005
1282005
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating
L He, AA Aleksandrov, AWR Serohijos, T Hegedüs, LA Aleksandrov, ...
Journal of Biological Chemistry 283 (39), 26383-26390, 2008
1232008
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins
T Hegedüs, T Sessler, R Scott, W Thelin, É Bakos, A Váradi, K Szabó, ...
Biochemical and biophysical research communications 302 (3), 454-461, 2003
1102003
Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?
A Brózik, C Hegedüs, Z Erdei, T Hegedűs, C Özvegy-Laczka, G Szakács, ...
Expert opinion on drug metabolism & toxicology 7 (5), 623-642, 2011
1062011
Nucleotide Occlusion in the Human Cystic Fibrosis Transmembrane Conductance Regulator DIFFERENT PATTERNS IN THE TWO NUCLEOTIDE BINDING DOMAINS
K Szabó, G Szakács, T Hegedűs, B Sarkadi
Journal of Biological Chemistry 274 (18), 12209-12212, 1999
981999
Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR
T Hegedűs, AWR Serohijos, NV Dokholyan, L He, JR Riordan
Journal of molecular biology 378 (5), 1052-1063, 2008
662008
Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A
T Hegedűs, A Aleksandrov, A Mengos, L Cui, TJ Jensen, JR Riordan
Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (6), 1341-1349, 2009
622009
F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive
T Hegedűs, A Aleksandrov, L Cui, M Gentzsch, XB Chang, JR Riordan
Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (5), 565-572, 2006
612006
ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions
G Gyimesi, S Ramachandran, P Kota, NV Dokholyan, B Sarkadi, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (12), 2954-2964, 2011
522011
Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein
Á Telbisz, C Özvegy-Laczka, T Hegedűs, A Váradi, B Sarkadi
Biochemical Journal 450 (2), 387-395, 2013
502013
Diminished self-chaperoning activity of the ΔF508 mutant of CFTR results in protein misfolding
AWR Serohijos, T Hegedűs, JR Riordan, NV Dokholyan
PLoS Comput Biol 4 (2), e1000008, 2008
502008
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter
C Özvegy-Laczka, R Laczkó, C Hegedűs, T Litman, G Várady, K Goda, ...
Journal of Biological Chemistry 283 (38), 26059-26070, 2008
492008
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Artiklar 1–20