| Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor NE Kohl, SD Mosser, SJ DeSolms, EA Giuliani, DL Pompliano, ... Science 260 (5116), 1934-1937, 1993 | 850 | 1993 |
| Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. JB Gibbs, IS Sigal, M Poe, EM Scolnick Proceedings of the National Academy of Sciences 81 (18), 5704-5708, 1984 | 823 | 1984 |
| Sequence dependence of protein isoprenylation SL Moores, MD Schaber, SD Mosser, E Rands, MB O'Hara, VM Garsky, ... Journal of Biological Chemistry 266 (22), 14603-14610, 1991 | 763 | 1991 |
| Mechanism-based target identification and drug discovery in cancer research JB Gibbs Science 287 (5460), 1969-1973, 2000 | 761 | 2000 |
| Cloning of bovine GAP and its interaction with oncogenic ras p21 US Vogel, RAF Dixon, MD Schaber, RE Diehl, MS Marshall, EM Scolnick, ... Nature 335 (6185), 90-93, 1988 | 741 | 1988 |
| Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice NE Kohl, CA Omer, MW Conner, NJ Anthony, JP Davide, SJ Desolms, ... Nature medicine 1 (8), 792-797, 1995 | 717 | 1995 |
| Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic JB Gibbs, A Oliff, NE Kohl Cell 77 (2), 175-178, 1994 | 678 | 1994 |
| A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and-independent growth of human tumor cell lines L Sepp-Lorenzino, Z Ma, E Rands, NE Kohl, JB Gibbs, A Oliff, N Rosen Cancer Research 55 (22), 5302-5309, 1995 | 550 | 1995 |
| PDGF induction of tyrosine phosphorylation of GTPase activating protein CJ Molloy, DP Bottaro, TP Fleming, MS Marshall, JB Gibbs, SA Aaronson Nature 342 (6250), 711-714, 1989 | 550 | 1989 |
| Ras C-terminal processing enzymes—new drug targets? JB Gibbs Cell 65 (1), 1-4, 1991 | 514 | 1991 |
| The potential of farnesyltransferase inhibitors as cancer chemotherapeutics JB Gibbs, A Oliff Annual review of pharmacology and toxicology 37 (1), 143-166, 1997 | 418 | 1997 |
| S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein K Tanaka, M Nakafuku, T Satoh, MS Marshall, JB Gibbs, K Matsumoto, ... Cell 60 (5), 803-807, 1990 | 411 | 1990 |
| Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. JB Gibbs, DL Pompliano, SD Mosser, E Rands, RB Lingham, SB Singh, ... Journal of Biological Chemistry 268 (11), 7617-7620, 1993 | 408 | 1993 |
| Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP) JB Gibbs, MS Marshall, EM Scolnick, RA Dixon, US Vogel Journal of Biological Chemistry 265 (33), 20437-20442, 1990 | 382 | 1990 |
| Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival B Lutterbach, Q Zeng, LJ Davis, H Hatch, G Hang, NE Kohl, JB Gibbs, ... Cancer research 67 (5), 2081-2088, 2007 | 378 | 2007 |
| Steady-state kinetic mechanism of Ras farnesyl: protein transferase DL Pompliano, E Rands, MD Schaber, SD Mosser, NJ Anthony, JB Gibbs Biochemistry 31 (15), 3800-3807, 1992 | 376 | 1992 |
| Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects. IS Sigal, JB Gibbs, JS D'Alonzo, GL Temeles, BS Wolanski, SH Socher, ... Proceedings of the National Academy of Sciences 83 (4), 952-956, 1986 | 354 | 1986 |
| Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21. IS Sigal, JB Gibbs, JS D'Alonzo, EM Scolnick Proceedings of the National Academy of Sciences 83 (13), 4725-4729, 1986 | 353 | 1986 |
| Purification of ras GTPase activating protein from bovine brain. JB Gibbs, MD Schaber, WJ Allard, IS Sigal, EM Scolnick Proceedings of the National Academy of Sciences 85 (14), 5026-5030, 1988 | 333 | 1988 |
| Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin … GC Prendergast, JP Da Vide, SJ Desolms, EA Giuliani, SL Graham, ... Molecular and Cellular Biology 14 (6), 4193-4202, 1994 | 283 | 1994 |
