| Two crystal structures of the B1 immunoglobulin-binding domain of streptococcal protein G and comparison with NMR T Gallagher, P Alexander, P Bryan, GL Gilliland Biochemistry 33 (15), 4721-4729, 1994 | 502 | 1994 |
| Thermodynamic analysis of the folding of the streptococcal protein G IgG-binding domains B1 and B2: why small proteins tend to have high denaturation temperatures P Alexander, S Fahnestock, T Lee, J Orban, P Bryan Biochemistry 31 (14), 3597-3603, 1992 | 357 | 1992 |
| Protein engineering of subtilisin PN Bryan Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2000 | 328 | 2000 |
| Protein engineering of subtilisin BPN': enhanced stabilization through the introduction of two cysteines to form a disulfide bond MW Pantoliano, RC Ladner, PN Bryan, ML Rollence, JF Wood, TL Poulos Biochemistry 26 (8), 2077-2082, 1987 | 324 | 1987 |
| Site-directed mutagenesis and the role of the oxyanion hole in subtilisin. P Bryan, MW Pantoliano, SG Quill, HY Hsiao, T Poulos Proceedings of the National Academy of Sciences 83 (11), 3743-3745, 1986 | 322 | 1986 |
| A minimal sequence code for switching protein structure and function PA Alexander, Y He, Y Chen, J Orban, PN Bryan Proceedings of the National Academy of Sciences 106 (50), 21149-21154, 2009 | 301 | 2009 |
| Large increases in general stability for subtilisin BPN'through incremental changes in the free energy of unfolding MW Pantoliano, M Whitlow, JF Wood, SW Dodd, KD Hardman, ... Biochemistry 28 (18), 7205-7213, 1989 | 297 | 1989 |
| The design and characterization of two proteins with 88% sequence identity but different structure and function PA Alexander, Y He, Y Chen, J Orban, PN Bryan Proceedings of the National Academy of Sciences 104 (29), 11963-11968, 2007 | 238 | 2007 |
| Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations CH Wong, ST Chen, WJ Hennen, JA Bibbs, YF Wang, JLC Liu, ... Journal of the American Chemical Society 112 (3), 945-953, 1990 | 234 | 1990 |
| Kinetic analysis of folding and unfolding the 56 amino acid IgG-binding domain of streptococcal protein G P Alexander, J Orban, P Bryan Biochemistry 31 (32), 7243-7248, 1992 | 232 | 1992 |
| The prosegment–subtilisin BPN′ complex: crystal structure of a specific ‘foldase’ T Gallagher, G Gilliland, L Wang, P Bryan Structure 3 (9), 907-914, 1995 | 229 | 1995 |
| The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case MW Pantoliano, M Whitlow, JF Wood, ML Rollence, BC Finzel, ... Biochemistry 27 (22), 8311-8317, 1988 | 228 | 1988 |
| Proteases of enhanced stability: characteization of a thermostable variant of subtilisin PN Brayan, ML Rollence, MW Pantoliano, J Wood, BC Finzel, GL Gilliland, ... Proteins: Structure, Function, and Bioinformatics 1 (4), 326-334, 1986 | 207 | 1986 |
| Proteins that switch folds PN Bryan, J Orban Current opinion in structural biology 20 (4), 482-488, 2010 | 204 | 2010 |
| Catalysis of a protein folding reaction: Mechanistic implications of the 2.0. ANG. structure of the subtilisin-prodomain complex P Bryan, L Wang, J Hoskins, S Ruvinov, S Strausberg, P Alexander, ... Biochemistry 34 (32), 10310-10318, 1995 | 143 | 1995 |
| Directed evolution of a subtilisin with calcium-independent stability SL Strausberg, PA Alexander, DT Gallagher, GL Gilliland, BL Barnett, ... Bio/technology 13 (7), 669-673, 1995 | 136 | 1995 |
| NMR structures of two designed proteins with high sequence identity but different fold and function Y He, Y Chen, P Alexander, PN Bryan, J Orban Proceedings of the National Academy of Sciences 105 (38), 14412-14417, 2008 | 134 | 2008 |
| Prodomains and protein folding catalysis PN Bryan Chemical reviews 102 (12), 4805-4816, 2002 | 128 | 2002 |
| Energetics of folding subtilisin BPN' P Bryan, P Alexander, S Strausberg, F Schwarz, W Lan, G Gilliland, ... Biochemistry 31 (21), 4937-4945, 1992 | 127 | 1992 |
| Conformational states of chromatin в bodies induced by urea DE Olins, PN Bryan, RE Harrington, WE Hill, AL Olins Nucleic Acids Research 4 (6), 1911-1932, 1977 | 114 | 1977 |
