| Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing A Le Thomas, E Stuwe, S Li, J Du, G Marinov, N Rozhkov, YCA Chen, ... Genes & development 28 (15), 1667-1680, 2014 | 210 | 2014 |
| Panoramix enforces piRNA-dependent cotranscriptional silencing Y Yu, J Gu, Y Jin, Y Luo, JB Preall, J Ma, B Czech, GJ Hannon Science 350 (6258), 339-342, 2015 | 183 | 2015 |
| A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila F Muerdter, PM Guzzardo, J Gillis, Y Luo, Y Yu, C Chen, R Fekete, ... Molecular cell 50 (5), 736-748, 2013 | 181 | 2013 |
| Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types S Ravindra Kumar, TF Miles, X Chen, D Brown, T Dobreva, Q Huang, ... Nature methods 17 (5), 541-550, 2020 | 142 | 2020 |
| T cell antigen discovery via trogocytosis G Li, MT Bethune, S Wong, AV Joglekar, MT Leonard, JK Wang, JT Kim, ... Nature methods 16 (2), 183-190, 2019 | 135 | 2019 |
| Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors YCA Chen, E Stuwe, Y Luo, M Ninova, A Le Thomas, E Rozhavskaya, ... Molecular cell 63 (1), 97-109, 2016 | 115 | 2016 |
| Minotaur is critical for primary piRNA biogenesis VV Vagin, Y Yu, A Jankowska, Y Luo, KA Wasik, CD Malone, E Harrison, ... Rna 19 (8), 1064-1077, 2013 | 75 | 2013 |
| Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila JK Hur, Y Luo, S Moon, M Ninova, GK Marinov, YD Chung, AA Aravin Genes & development 30 (7), 840-855, 2016 | 74 | 2016 |
| Su (var) 2-10 and the SUMO pathway link piRNA-guided target recognition to chromatin silencing M Ninova, YCA Chen, B Godneeva, AK Rogers, Y Luo, KF Tóth, ... Molecular cell 77 (3), 556-570. e6, 2020 | 71 | 2020 |
| The SUMO ligase Su (var) 2-10 controls hetero-and euchromatic gene expression via establishing H3K9 trimethylation and negative feedback regulation M Ninova, B Godneeva, YCA Chen, Y Luo, SJ Prakash, F Jankovics, ... Molecular cell 77 (3), 571-585. e4, 2020 | 42 | 2020 |
| RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility P Chen, Y Luo, AA Aravin PLoS genetics 17 (9), e1009591, 2021 | 22 | 2021 |
| Maternally inherited siRNAs initiate piRNA cluster formation Y Luo, P He, N Kanrar, KF Toth, AA Aravin Molecular Cell 83 (21), 3835-3851. e7, 2023 | 15 | 2023 |
| Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster Y Luo, E Fefelova, M Ninova, YCA Chen, AA Aravin Elife 9, e52416, 2020 | 11 | 2020 |
| AAV DNA library generation SR Kumar, TF Shay, X Chen, D Brown, T Dobreva, Q Huang, X Ding, ... | | 2023 |
| Cloning individual AAV capsid variants SR Kumar, TF Shay, X Chen, D Brown, T Dobreva, Q Huang, X Ding, ... | | 2023 |
| Library tissue handling, viral DNA extraction, and NGS sample preparation M Chuapoco, SR Kumar, TF Shay, X Chen, D Brown, T Dobreva, ... | | 2023 |
| Evolution and Investigation of Engineered AAV Capsids Exhibiting Enhanced Transduction of the Central Nervous System with or without Murine Strain Specificity R Kumar, TF Miles, X Chen, D Brown, T Dobreva, Q Huang, X Ding, Y Luo, ... MOLECULAR THERAPY 28 (4), 11-12, 2020 | | 2020 |
| Multiplexed-CREATE Selection Yields AAV Vectors Targeting Different Cell Types of the Central Nervous System Following Systemic Delivery SR Kumar, X Chen, BE Deverman, D Brown, T Dobreva, Q Huang, X Ding, ... MOLECULAR THERAPY 27 (4), 53-53, 2019 | | 2019 |
| Developing AAV Vectors for More Efficient and Selective Gene Expression in Specific Cell Types of the Nervous System Following Systemic Delivery R Kumar, K Sripriya Chan, MJ Jang, Q Huang, D Brown, T Dobreva, ... MOLECULAR THERAPY 26 (5), 321-321, 2018 | | 2018 |
| The SUMO ligase Su (var) 2-10 controls eu-and heterochromatic gene expression via establishment of H3K9 trimethylation and negative feedback regulation M Ninova, B Godneeva, YCA Chen, Y Luo, SJ Prakash, F Jankovics, ... | | |
Alexei AravinProfessor, Division of Biology and Biological Engineering, California Institute of TechnologyVerified email at caltech.edu
