Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium RV Shohet, S Chen, YT Zhou, Z Wang, RS Meidell, RH Unger, ... Circulation 101 (22), 2554-2556, 2000 | 644 | 2000 |
Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart R Bekeredjian, S Chen, PA Frenkel, PA Grayburn, RV Shohet Circulation 108 (8), 1022-1026, 2003 | 436 | 2003 |
Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction S Chen, RV Shohet, R Bekeredjian, P Frenkel, PA Grayburn Journal of the American College of Cardiology 42 (2), 301-308, 2003 | 290 | 2003 |
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology S Chen, J Ding, R Bekeredjian, B Yang, RV Shohet, SA Johnston, ... Proceedings of the National Academy of Sciences 103 (22), 8469-8474, 2006 | 248 | 2006 |
DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro PA Frenkel, S Chen, T Thai, RV Shohet, PA Grayburn Ultrasound in medicine & biology 28 (6), 817-822, 2002 | 234 | 2002 |
Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles G Korpanty, S Chen, RV Shohet, J Ding, B Yang, PA Frenkel, ... Gene therapy 12 (17), 1305-1312, 2005 | 188 | 2005 |
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome MY Wang, P Grayburn, S Chen, M Ravazzola, L Orci, RH Unger Proceedings of the National Academy of Sciences 105 (16), 6139-6144, 2008 | 171 | 2008 |
Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction R Bekeredjian, S Chen, PA Grayburn, RV Shohet Ultrasound in medicine & biology 31 (5), 687-691, 2005 | 127 | 2005 |
Bioeffects of myocardial contrast microbubble destruction by echocardiography S Chen, MH Kroll, RV Shohet, P Frenkel, SA Mayer, PA Grayburn Echocardiography 19 (6), 495-500, 2002 | 93 | 2002 |
Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice JS Shen, A Busch, TS Day, XL Meng, CI Yu, P Dabrowska-Schlepp, ... Journal of inherited metabolic disease 39, 293-303, 2016 | 89 | 2016 |
Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy S Chen, M Shimoda, MY Wang, J Ding, H Noguchi, S Matsumoto, ... Gene therapy 17 (11), 1411-1420, 2010 | 75 | 2010 |
Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1 S Chen, J Ding, C Yu, B Yang, DR Wood, PA Grayburn Gene therapy 14 (14), 1102-1110, 2007 | 69 | 2007 |
Gene or drug delivery system P Grayburn, C Shuyuan US Patent App. 11/198,210, 2007 | 66 | 2007 |
In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into … M Shimoda, S Chen, H Noguchi, S Matsumoto, PA Grayburn Diabetologia 53, 1669-1679, 2010 | 61 | 2010 |
Effects of ultrasound-targeted microbubble destruction on cardiac gene expression R Bekeredjian, S Chen, W Pan, PA Grayburn, RV Shohet Ultrasound in medicine & biology 30 (4), 539-543, 2004 | 56 | 2004 |
Stimulation of adult resident cardiac progenitor cells by durable myocardial expression of thymosin beta 4 with ultrasound-targeted microbubble delivery S Chen, M Shimoda, J Chen, PA Grayburn Gene therapy 20 (2), 225-233, 2013 | 49 | 2013 |
Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration S Chen, M Shimoda, J Chen, S Matsumoto, PA Grayburn Cell Cycle 11 (4), 695-705, 2012 | 49 | 2012 |
In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats J Chen, S Chen, P Huang, XL Meng, S Clayton, JS Shen, PA Grayburn Diabetologia 58, 1036-1044, 2015 | 46 | 2015 |
Anti-tumor efficacy of ultrasonic cavitation is potentiated by concurrent delivery of anti-angiogenic drug in colon cancer C Zhang, P Huang, Y Zhang, J Chen, W Shentu, Y Sun, Z Yang, S Chen Cancer Letters 347 (1), 105-113, 2014 | 46 | 2014 |
Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1 S Chen, RA Bastarrachea, BJ Roberts, VS Voruganti, PA Frost, ... Cell Cycle 13 (7), 1145-1151, 2014 | 44 | 2014 |