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Laura Wittemans
Laura Wittemans
Sir Henry Wellcome Fellow, University of Oxford
Verifierad e-postadress på wrh.ox.ac.uk
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Using human genetics to understand the disease impacts of testosterone in men and women
KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood, A Mahajan, ...
Nature medicine 26 (2), 252-258, 2020
4612020
Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors
LA Lotta, LBL Wittemans, V Zuber, ID Stewart, SJ Sharp, J Luan, FR Day, ...
Jama 320 (24), 2553-2563, 2018
1722018
A cross-platform approach identifies genetic regulators of human metabolism and health
LA Lotta, M Pietzner, ID Stewart, LBL Wittemans, C Li, R Bonelli, J Raffler, ...
Nature Genetics 53 (1), 54-64, 2021
1252021
Assessing the causal association of glycine with risk of cardio-metabolic diseases
LBL Wittemans, LA Lotta, C Oliver-Williams, ID Stewart, P Surendran, ...
Nature communications 10 (1), 1060, 2019
1052019
Association of genetically enhanced lipoprotein lipase–mediated lipolysis and low-density lipoprotein cholesterol–lowering alleles with risk of coronary disease and type 2 diabetes
LA Lotta, ID Stewart, SJ Sharp, FR Day, S Burgess, J Luan, N Bowker, ...
JAMA cardiology 3 (10), 957-966, 2018
762018
Obesity and risk of female reproductive conditions: A Mendelian randomisation study
SS Venkatesh, T Ferreira, S Benonisdottir, N Rahmioglu, CM Becker, ...
PLoS medicine 19 (2), e1003679, 2022
732022
Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran, ID Stewart, VPW Au Yeung, M Pietzner, J Raffler, ...
Nature Medicine 28 (11), 2321-2332, 2022
542022
Insights into genetic variants associated with NASH-fibrosis from metabolite profiling
JP Mann, M Pietzner, LB Wittemans, EDL Rolfe, ND Kerrison, F Imamura, ...
Human molecular genetics 29 (20), 3451-3463, 2020
372020
Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity
H Yaghootkar, Y Zhang, CN Spracklen, T Karaderi, LO Huang, J Bradfield, ...
Diabetes 69 (12), 2806-2818, 2020
302020
Exome-derived adiponectin-associated variants implicate obesity and lipid biology
CN Spracklen, T Karaderi, H Yaghootkar, C Schurmann, RS Fine, ...
The American Journal of Human Genetics 105 (1), 15-28, 2019
262019
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition
C Hilton, MJ Neville, LBL Wittemans, M Todorcevic, KE Pinnick, SL Pulit, ...
EBioMedicine 44, 467-475, 2019
222019
Evidence from men for ovary-independent effects of genetic risk factors for polycystic ovary syndrome
J Zhu, N Pujol-Gualdo, LBL Wittemans, CM Lindgren, T Laisk, ...
The Journal of Clinical Endocrinology & Metabolism 107 (4), e1577-e1587, 2022
212022
HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution
FC Kuo, MJ Neville, R Sabaratnam, A Wesolowska-Andersen, D Phillips, ...
Cell reports 40 (4), 2022
182022
Identification of rare loss-of-function genetic variation regulating body fat distribution
M Koprulu, Y Zhao, E Wheeler, L Dong, N Rocha, C Li, JD Griffin, S Patel, ...
The Journal of Clinical Endocrinology & Metabolism 107 (4), 1065-1077, 2022
162022
Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
LA Lotta, M Pietzner, ID Stewart, LBL Wittemans, C Li, R Bonelli, J Raffler, ...
Nature genetics 53 (1), 54, 2021
132021
Regional fat depot masses are influenced by protein-coding gene variants
MJ Neville, LBL Wittemans, KE Pinnick, M Todorčević, R Kaksonen, ...
PloS one 14 (5), e0217644, 2019
122019
Endometrial Cancer Association C, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB. Using human genetics to understand the …
KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood, A Mahajan, ...
Nat Med 26 (2), 252-258, 2020
112020
Prioritising risk factors for type 2 diabetes: causal inference through genetic approaches
LBL Wittemans, LA Lotta, C Langenberg
Current Diabetes Reports 18, 1-10, 2018
72018
A genetically defined male counterpart of polycystic ovary syndrome: Evidence for ovarian-independent pathogenesis
J Zhu, LBL Wittemans, C Lindgren, JN Hirschhorn, YM Chan
Journal of the Endocrine Society 5 (Suppl 1), A773, 2021
52021
Machine learning-based steroid metabolome analysis reveals three distinct subtypes of polycystic ovary syndrome and implicates 11-oxygenated androgens as major drivers of …
E Melson, TP Rocha, RJ Veen, L Abdi, T Mcdonnell, V Tandl, JM Hawley, ...
Endocrine Abstracts 90, 2023
32023
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Artiklar 1–20