| Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs JA Gagnon, E Valen, SB Thyme, P Huang, L Ahkmetova, A Pauli, ... PloS one 9 (5), e98186, 2014 | 980 | 2014 |
| CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering K Labun, TG Montague, JA Gagnon, SB Thyme, E Valen Nucleic acids research 44 (W1), W272-W276, 2016 | 951 | 2016 |
| Macromolecular modeling and design in Rosetta: recent methods and frameworks JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ... Nature methods 17 (7), 665-680, 2020 | 561 | 2020 |
| A synthetic homing endonuclease-based gene drive system in the human malaria mosquito N Windbichler, M Menichelli, PA Papathanos, SB Thyme, H Li, UY Ulge, ... Nature 473 (7346), 212-215, 2011 | 409 | 2011 |
| Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions SB Thyme, LM Pieper, EH Li, S Pandey, Y Wang, NS Morris, C Sha, ... Cell 177 (2), 478-491. e20, 2019 | 171 | 2019 |
| Internal guide RNA interactions interfere with Cas9-mediated cleavage SB Thyme, L Akhmetova, TG Montague, E Valen, AF Schier Nature communications 7 (1), 11750, 2016 | 166 | 2016 |
| Kctd13 deletion reduces synaptic transmission via increased RhoA CO Escamilla, I Filonova, AK Walker, ZX Xuan, R Holehonnur, F Espinosa, ... Nature 551 (7679), 227-231, 2017 | 145 | 2017 |
| Exploitation of binding energy for catalysis and design SB Thyme, J Jarjour, R Takeuchi, JJ Havranek, J Ashworth, ... Nature 461 (7268), 1300-1304, 2009 | 110 | 2009 |
| Polq-mediated end joining is essential for surviving DNA double-strand breaks during early zebrafish development SB Thyme, AF Schier Cell reports 15 (4), 707-714, 2016 | 84 | 2016 |
| Mechanistic Study of Competitive sp3-sp3 and sp2-sp3 Carbon-Carbon Reductive Elimination from a Platinum (IV) Center and the Isolation of a CC Agostic Complex L Brian, B Summer, S Keene, BS Williams Journal of the American Chemical Society 129 (31), 9538-9539, 2007 | 57 | 2007 |
| Reprogramming homing endonuclease specificity through computational design and directed evolution SB Thyme, SJS Boissel, S Arshiya Quadri, T Nolan, DA Baker, RU Park, ... Nucleic acids research 42 (4), 2564-2576, 2014 | 36 | 2014 |
| Improved modeling of side-chain–base interactions and plasticity in protein–DNA interface design SB Thyme, D Baker, P Bradley Journal of molecular biology 419 (3-4), 255-274, 2012 | 21 | 2012 |
| Massively parallel determination and modeling of endonuclease substrate specificity SB Thyme, Y Song, TJ Brunette, MD Szeto, L Kusak, P Bradley, D Baker Nucleic acids research 42 (22), 13839-13852, 2014 | 16 | 2014 |
| Mining endonuclease cleavage determinants in genomic sequence data MD Szeto, SJS Boissel, D Baker, SB Thyme Journal of Biological Chemistry 286 (37), 32617-32627, 2011 | 16 | 2011 |
| A customizable low-cost system for massively parallel zebrafish behavioral phenotyping W Joo, MD Vivian, BJ Graham, ER Soucy, SB Thyme Frontiers in Behavioral Neuroscience 14, 606900, 2021 | 13 | 2021 |
| Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus Y Wang, IF Khan, S Boissel, J Jarjour, J Pangallo, S Thyme, D Baker, ... Nucleic Acids Research 42 (10), 6463-6475, 2014 | 12 | 2014 |
| Redesigning the specificity of protein–DNA interactions with Rosetta S Thyme, D Baker Homing Endonucleases: Methods and Protocols, 265-282, 2014 | 12 | 2014 |
| Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish BK Robens, X Yang, CM McGraw, LH Turner, C Robens, S Thyme, ... Neurobiology of disease 169, 105738, 2022 | 9 | 2022 |
| A single-cell transcriptome atlas of the maturing zebrafish telencephalon S Pandey, AJ Moyer, SB Thyme Genome Research 33 (4), 658-671, 2023 | 8 | 2023 |
| Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition JU Park, MT Petassi, SC Hsieh, E Mehrotra, G Schuler, J Budhathoki, ... Molecular Cell 83 (11), 1827-1838. e6, 2023 | 4 | 2023 |
