RNAi therapeutics: principles, prospects and challenges L Aagaard, JJ Rossi Advanced drug delivery reviews 59 (2-3), 75-86, 2007 | 1165 | 2007 |
Distance constraints between microRNA target sites dictate efficacy and cooperativity P Sætrom, BSE Heale, O Snøve Jr, L Aagaard, J Alluin, JJ Rossi Nucleic acids research 35 (7), 2333-2342, 2007 | 453 | 2007 |
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells MS Weinberg, LM Villeneuve, ALI Ehsani, M Amarzguioui, L Aagaard, ... Rna 12 (2), 256-262, 2006 | 372 | 2006 |
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC D Castanotto, K Sakurai, R Lingeman, H Li, L Shively, L Aagaard, H Soifer, ... Nucleic acids research 35 (15), 5154-5164, 2007 | 328 | 2007 |
Identification of endogenous retroviral reading frames in the human genome P Villesen, L Aagaard, C Wiuf, FS Pedersen Retrovirology 1, 1-13, 2004 | 230 | 2004 |
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity R Kang, Y Zhou, S Tan, G Zhou, L Aagaard, L Xie, C Bünger, L Bolund, ... Stem cell research & therapy 6, 1-14, 2015 | 125 | 2015 |
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity T Brudek, T Christensen, L Aagaard, T Petersen, HJ Hansen, ... Retrovirology 6, 1-13, 2009 | 113 | 2009 |
Molecular mechanisms in DM1—a focus on foci OJ Pettersson, L Aagaard, TG Jensen, CK Damgaard Nucleic acids research 43 (4), 2433-2441, 2015 | 104 | 2015 |
A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha L Aagaard, M Amarzguioui, G Sun, LC Santos, A Ehsani, H Prydz, ... Molecular Therapy 15 (5), 938-945, 2007 | 78 | 2007 |
Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy AL Askou, S Alsing, JNE Benckendorff, A Holmgaard, JG Mikkelsen, ... Molecular Therapy-Nucleic Acids 16, 38-50, 2019 | 58 | 2019 |
DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1 OJ Pettersson, L Aagaard, D Andrejeva, R Thomsen, TG Jensen, ... Nucleic acids research 42 (11), 7186-7200, 2014 | 55 | 2014 |
Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA-and protein-based antiangiogenic factors AL Askou, L Aagaard, C Kostic, Y Arsenijevic, AK Hollensen, T Bek, ... Molecular Therapy Methods & Clinical Development 2, 2015 | 51 | 2015 |
Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution AL Kjeldbjerg, P Villesen, L Aagaard, FS Pedersen BMC Evolutionary Biology 8, 1-11, 2008 | 51 | 2008 |
Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system Y Zhou, Y Liu, D Hussmann, P Brøgger, RA Al-Saaidi, S Tan, L Lin, ... Cellular and Molecular Life Sciences 73, 2543-2563, 2016 | 48 | 2016 |
Adeno‐associated virus‐delivered polycistronic microRNA‐clusters for knockdown of vascular endothelial growth factor in vivo M Pihlmann, AL Askou, L Aagaard, GH Bruun, JD Svalgaard, ... The journal of gene medicine 14 (5), 328-338, 2012 | 45 | 2012 |
Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs AL Askou, JNE Benckendorff, A Holmgaard, T Storm, L Aagaard, T Bek, ... Human gene therapy methods 28 (4), 222-233, 2017 | 29 | 2017 |
Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5 A Ehsani, P Saetrom, J Zhang, J Alluin, H Li, O Snøve Jr, L Aagaard, ... Molecular Therapy 18 (4), 796-802, 2010 | 29 | 2010 |
Improved lentiviral gene delivery to mouse liver by hydrodynamic vector injection through tail vein T Dalsgaard, CR Cecchi, AL Askou, RO Bak, PO Andersen, D Hougaard, ... Molecular Therapy-Nucleic Acids 12, 672-683, 2018 | 26 | 2018 |
Mitochondrial spare respiratory capacity is negatively correlated with nuclear reprogramming efficiency Y Zhou, RA Al-Saaidi, P Fernandez-Guerra, KK Freude, RKJ Olsen, ... Stem cells and development 26 (3), 166-176, 2017 | 25 | 2017 |
The∼ 30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys L Aagaard, P Villesen, AL Kjeldbjerg, FS Pedersen Genomics 86 (6), 685-691, 2005 | 23 | 2005 |