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Constantin Giurgiu
Constantin Giurgiu
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Common and potentially prebiotic origin for precursors of nucleotide synthesis and activation
AC Fahrenbach, C Giurgiu, CP Tam, L Li, Y Hongo, M Aono, JW Szostak
Journal of the American Chemical Society 139 (26), 8780-8783, 2017
852017
Non-enzymatic primer extension with strand displacement
L Zhou, SC Kim, KH Ho, DK O'Flaherty, C Giurgiu, TH Wright, JW Szostak
Elife 8, e51888, 2019
472019
The emergence of RNA from the heterogeneous products of prebiotic nucleotide synthesis
SC Kim, DK O’Flaherty, C Giurgiu, L Zhou, JW Szostak
Journal of the American Chemical Society 143 (9), 3267-3279, 2021
262021
A mechanistic explanation for the regioselectivity of nonenzymatic RNA primer extension
C Giurgiu, L Li, DK O’Flaherty, CP Tam, JW Szostak
Journal of the American Chemical Society 139 (46), 16741-16747, 2017
232017
Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates
D Ding, L Zhou, C Giurgiu, JW Szostak
Nucleic Acids Research 50 (1), 35-45, 2022
222022
Prebiotically plausible “patching” of RNA backbone cleavage through a 3′–5′ pyrophosphate linkage
TH Wright, C Giurgiu, W Zhang, A Radakovic, DK O’Flaherty, L Zhou, ...
Journal of the American Chemical Society 141 (45), 18104-18112, 2019
202019
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying
C Giurgiu, TH Wright, DK O'Flaherty, JW Szostak
Angewandte Chemie International Edition 57 (31), 9844-9848, 2018
132018
Structure–Activity Relationships in Nonenzymatic Template‐Directed RNA Synthesis
C Giurgiu, Z Fang, HRM Aitken, SC Kim, L Pazienza, S Mittal, JW Szostak
Angewandte Chemie International Edition 60 (42), 22925-22932, 2021
112021
Investigating the Mechanism of Non-Enzymatic RNA Replication
C Giurgiu
Harvard University, 2021
2021
Supporting information A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension
C Giurgiu, L Li, DK O’Flaherty, CP Tam, JW Szostak
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